Blood platelet membrane fluidity and the exposition of membrane protein receptors in Alzheimer disease (AD) patients - Preliminary study

We estimated membrane fluidity by the (ESR) spectroscopy and the expression of membrane P-selectin and glycoproteins GP Ibalpha and GP IIb/IIIa by flow cytometry in platelets (plts) from 12 AD sufferers. In AD patients membrane fluidity was significantly increased at two different depths (p<0.05 or less). Platelet reactivity was significantly decreased, as reflected by reduced expression of GP Ibα in the resting (p<0.0001) and activated (p<0.005) platelets, as well as the expression of P-selectin and β(3) subunit of GP IIb/IIa in activated platelets (p<0.0001; p<0.04).