Accumulation of organotins in seafood leads to reproductive tract abnormalities in female rats

被引:37
|
作者
Podratz, Priscila L. [1 ]
Merlo, Eduardo [1 ]
Sena, Gabriela C. [1 ]
Morozesk, Mariana [2 ]
Bonomo, Marina M. [2 ]
Matsumoto, Silvia T. [2 ]
da Costa, Mercia B. [2 ]
Zamprogno, Gabriela C. [2 ]
Brandao, Poliane A. A. [3 ]
Carneiro, Maria T. W. D. [3 ]
Miguel, Emilio de C. [4 ]
Miranda-Alves, Leandro [5 ]
Silva, Ian V. [1 ]
Graceli, Jones B. [1 ]
机构
[1] Univ Fed Espirito Santo, Dept Morphol, Vitoria, ES, Brazil
[2] Univ Fed Espirito Santo, Dept Biol Sci, Vitoria, ES, Brazil
[3] Univ Fed Espirito Santo, Dept Chem, Vitoria, ES, Brazil
[4] Univ Fed Ceara, Dept Biochem & Mol Biol, Fortaleza, Ceara, Brazil
[5] Univ Fed Rio de Janeiro, Inst Biomed Sci, Expt Endocrinol Res Grp, BR-21941 Rio De Janeiro, Brazil
关键词
Environmental contamination; Organotins accumulated in seafood; Endocrine disruption; Reproductive toxicity; ESTROGEN-RECEPTOR-ALPHA; TRIBUTYLTIN CHLORIDE; BUTYLTIN COMPOUNDS; IN-VITRO; NONSPECIFIC RESISTANCE; TISSUE DISTRIBUTION; SEXUAL DEVELOPMENT; GENE-EXPRESSION; DIETARY-INTAKE; MUD SNAIL;
D O I
10.1016/j.reprotox.2015.05.003
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Organotins (OTs) are environmental contaminants used as biocides in antifouling paints that have been shown to be endocrine disrupters. However, studies evaluating the effects of OTs accumulated in seafood (LNI) on reproductive health are particularly sparse. This study demonstrates that LNI leads to impairment in the reproductive tract of female rats, as the estrous cycle development, as well as for ovary and uterus morphology. Rats were treated with LNI, and their reproductive morphophysiology was assessed. Morphophysiological abnormalities, such as irregular estrous cycles, abnormal ovarian follicular development and ovarian collagen deposition, were observed in LNI rats. An increase in luminal epithelia and ER alpha expression was observed in the LNI uteri. Together, these data provide in vivo evidence that LNI are toxic for reproductive morphophysiology, which may be associated with risks to reproductive function. (C) 2015 Elsevier Inc. All rights reserved.
引用
收藏
页码:29 / 42
页数:14
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