Novel Poly(3-hydroxyoctanoate)/Poly(3-hydroxybutyrate) blends for medical applications

被引：56

作者：

Basnett, P. ^{[1
]}

Ching, K. Y. ^{[3
]}

Stolz, M. ^{[3
]}

Knowles, J. C. ^{[4
,5
]}

Boccaccini, A. R. ^{[6
]}

Smith, C. ^{[1
]}

Locke, I. C. ^{[2
]}

Keshavarz, T. ^{[1
]}

Roy, I. ^{[1
]}

机构：

[1] Univ Westminster, Sch Life Sci, Dept Appl & Mol Biosci, London W1W 6UW, England

[2] Univ Westminster, Sch Life Sci, Dept Biomed Sci, London W1W 6UW, England

[3] Univ Southampton, NCATS, Southampton SO17 1BJ, Hants, England

[4] UCL, UCL Eastman Dent Inst, Div Biomat & Tissue Engn, London WC1X 8LD, England

[5] Dankook Univ, WCU Res Ctr Nanobiomed Sci, Cheonan Si 330714, Chungnam, South Korea

[6] Univ Erlangen Nurnberg, Inst Biomat, Dept Mat Sci & Engn, D-91058 Erlangen, Germany

来源：

REACTIVE & FUNCTIONAL POLYMERS | 2013年 / 73卷 / 10期

基金：

英国工程与自然科学研究理事会;

关键词：

Polyhydroxyalkanoates; Cytotoxicity; Biodegradability; Poly(3-hydroxyoctanoate); Poly(3-hydroxybutyrate); POLYHYDROXYALKANOATES; BIODEGRADABILITY; MISCIBILITY; DEGRADATION; SCAFFOLDS;

D O I：

10.1016/j.reactfunctpolym.2013.03.019

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Novel Poly(3-hydroxybutyrate)/Poly(3-hydroxyoctanoate) blends were developed with varying amounts of Poly(3-hydroxyoctanoate), P(3HO) and Poly(3-hydroxybutyrate), P(3HB) for their potential use in various medical applications. These blend films exhibited higher tensile strength and Young's modulus values compared to neat P(3HO). The overall protein adsorption and % cell viability was also found to be significantly higher in the blend films than the neat P(3HO) film. Hydrolytic degradation was faster in the blend films and the degradation rate could potentially be tailored to achieve the optimum rate required for a particular medical application. Hence, these novel blends were found to be highly biocompatible with surface, mechanical and thermal properties suitable for a range of potential medical applications, a great step forward in the area of medical materials. (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：1340 / 1348

页数：9

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