Off-label use of rituximab in dermatology: pemphigus treatment

被引：12

作者：

Bomm, Lislaine ^{[1
]}

Fracaroli, Taina Scalfoni ^{[1
]}

Sodre, Joao Luz ^{[1
]}

Bressan, Aline ^{[1
]}

Gripp, Alexandre Carlos ^{[1
]}

机构：

[1] State Univ Rio de Janeiro HUPE UERJ, Pedro Ernesto Univ Hosp, Rio De Janeiro, RJ, Brazil

来源：

ANAIS BRASILEIROS DE DERMATOLOGIA | 2013年 / 88卷 / 04期

关键词：

biological treatment; immunosuppressive agents; pemphigus;

D O I：

10.1590/abd1806-4841.20131905

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Since its approval in 1997 by the FDA (United States Food and Drug Administration), rituximab has been used for certain B-cell lymphomas and treatment-resistant rheumatoid arthritis. Nevertheless, over the past 14 years, many case reports have demonstrated the efficacy of off-label rituximab in several dermatological inflammatory conditions. This study describes two cases of pemphigus vulgaris and two cases of pemphigus foliaceous that were treated with rituximab at 375 mg/m(2) once a week for 4 weeks, and that responded well to treatment.

引用

页码：676 / 678

页数：3

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