Tumor necrosis factor alpha-308 gene polymorphism and pseudoexfoliation glaucoma

被引：0

作者：

Tekeli, Oya ^{[1
]}

Turacli, M. Erol ^{[1
]}

Egin, Yonca ^{[2
]}

Akar, Nejat ^{[2
]}

Elhan, Atilla Halil ^{[3
]}

机构：

[1] Ankara Univ, Sch Med, Dept Ophthalmol, TR-06100 Ankara, Turkey

[2] Ankara Univ, Sch Med, Dept Pediat Genet, TR-06100 Ankara, Turkey

[3] Ankara Univ, Sch Med, Dept Biostat, TR-06100 Ankara, Turkey

来源：

MOLECULAR VISION | 2008年 / 14卷 / 212-14期

关键词：

D O I：

暂无

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Purpose: To investigate the possible association between tumor necrosis factor alpha (TNF-alpha)-308 G/A polymorphism and pseudoexfoliation (PEX) glaucoma. Methods: One hundred and ten Turkish PEX glaucoma patients and 110 healthy control subjects were enrolled in the study. All participants underwent a complete ophthalmic examination. TNF-alpha-308 was genotyped by polymerase chain reaction and restriction endonuclease analysis. Results: We found a high prevalence of the G/G genotype in PEX glaucoma patients (OR= 2.88, 95% CI 1.15-7.20). The A polymorphic allele frequency was 3.2% in patients with PEX compared with 8.2% in controls (p= 0.023). Conclusions: Our results suggest that TNF-alpha-308 G/A genotype is not associated with PEX glaucoma. The -308G/A variant may be a possible protective factor against PEX.

引用

页码：1815 / 1818

页数：4

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