Development of a Continuous Flow Scale-Up Approach of Reflux Inhibitor AZD6906

被引：25

作者：

Gustafsson, Tomas ^{[1
]}

Sorensen, Henrik ^{[1
]}

Ponten, Fritiof ^{[1
]}

机构：

[1] AstraZeneca R&D, Med Chem, SE-43183 Molndal, Sweden

来源：

ORGANIC PROCESS RESEARCH & DEVELOPMENT | 2012年 / 16卷 / 05期

关键词：

ORGANIC-SYNTHESIS;

D O I：

10.1021/op200340c

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Early scale-up work of a promising reflux inhibitor AZD6906 is described. Two steps of an earlier route were adapted to be performed in continuous flow to avoid issues related to batch procedures, resulting in a robust method with reduced cost of goods and improved product quality. Toxic and reactive reagents and starting materials could be handled in a flow regime, thereby allowing safer and more convenient reaction optimization and production.

引用

页码：925 / 929

页数：5

共 50 条

[21] Development and Scale-Up of an Improved Manufacturing Route to the ATR Inhibitor Ceralasertib
Graham, Mark A.
Askey, Hannah
Campbell, Andrew D.
Chan, Lai
Cooper, Katie G.
Cui, Zhaoshan
Dalgleish, Andrew
Dave, David
Ensor, Gareth
Espinosa, Maria Rita Galan
Hamilton, Peter
Heffernan, Claire
Jackson, Lucinda, V
Jing, Dajiang
Jones, Martin F.
Liu, Pengpeng
Mulholland, Keith R.
Pervez, Mohammed
Popadynec, Michael
Randles, Emma
Tomasi, Simone
Wang, Shenghua
ORGANIC PROCESS RESEARCH & DEVELOPMENT, 2021, 25 (01) : 43 - 56
[22] Development and Scale-Up of a Continuous Manufacturing Process for a Hydrazine Condensation Reaction
Zhu, Ruiheng
Reddy, Ramesh
Ding, Man
Xu, Ming
Deng, Chaoyi
Tadayon, Sam
Li, Hui
Depew, Kristopher
Lane, Benjamin
ORGANIC PROCESS RESEARCH & DEVELOPMENT, 2021, 25 (02) : 199 - 205
[23] Process Development and Scale-Up of a Benzoxazepine-Containing Kinase Inhibitor
Naganathan, Sriram
Andersen, Denise L.
Andersen, Neil G.
Lau, Stephen
Lohse, Anders
Sorensen, Mads Detlef
ORGANIC PROCESS RESEARCH & DEVELOPMENT, 2015, 19 (07) : 721 - 734
[24] Benefits of continuous flow manufacturing in a time of change Challenges of an efficient continuous flow process and scale-up for azides
Kaiser, Patrick
Fricke, Yvonne
Kulkarni, Yashwant
Solchinger, Alexander
Wille, Gregor
CHIMICA OGGI-CHEMISTRY TODAY, 2014, 32 (06) : 38 - 42
[25] Initial results from a commercial continuous flow microwave reactor for scale-up
Moseley, Jonathan D.
Lawton, Simon J.
CHIMICA OGGI-CHEMISTRY TODAY, 2008, 26 (01) : 8 - 10
[26] Combining radial and continuous flow synthesis to optimize and scale-up the production of medicines
Guidi, Mara
Moon, Sooyeon
Anghileri, Lucia
Cambie, Dario
Seeberger, Peter H.
Gilmore, Kerry
REACTION CHEMISTRY & ENGINEERING, 2021, 6 (02) : 220 - 224
[27] Enabling Technologies in Pharmaceutical Industry Scale-up of Hazardous Reactions in Continuous Flow
Brocklehurst, Cara E.
La Vecchia, Luigi
Lehmann, Hansjoerg
CHIMICA OGGI-CHEMISTRY TODAY, 2014, 32 (04) : 30 - 34
[28] Experience with Scale-Up of Low-Temperature Organometallic Reactions in Continuous Flow
Laue, Stephan
Haverkamp, Verena
Mleczko, Leslaw
ORGANIC PROCESS RESEARCH & DEVELOPMENT, 2016, 20 (02) : 480 - 486
[29] Initial results from a Commercial continuous flow microwave reactor for scale-up
Moseley, Jonathan D.
Lawton, Simon J.
CHIMICA OGGI-CHEMISTRY TODAY, 2007, 25 (02) : 16 - 19
[30] SCALE-UP OF COCURRENT FLOW EXTRACTORS
LONG, RB
INDUSTRIAL & ENGINEERING CHEMISTRY FUNDAMENTALS, 1962, 1 (02): : 152 - &

← 1 2 3 4 5 →