Cxcr4low FLT3/ITD+ Cells Exhibit Enhanced Resistance to the FLT3 Inhibitor Quizartinib Compared to Cxcr4high FLT3/ITD+ Cells By Elevating Runx1 Expression

被引:0
|
作者
Fukuda, Seiji [1 ]
Onishi, Chie [2 ]
Taketani, Takeshi [3 ]
机构
[1] Shimane Univ, Sch Med, Dept Pediat, Dept Clin Nursing, Izumo, Shimane, Japan
[2] Shimane Univ, Shimane Univ Hosp, Clin Res Ctr, Dept Oncol & Hematol,Sch Med, Izumo, Shimane, Japan
[3] Shimane Univ, Sch Med, Dept Pediat, Izumo, Shimane, Japan
关键词
D O I
10.1182/blood-2019-129513
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
129513
引用
收藏
页数:3
相关论文
共 50 条
  • [31] Co-expression of wild-type FLT3 attenuates the inhibitory effect of FLT3 inhibitor on FLT3 mutated leukemia cells
    Chen, Fangli
    Ishikawa, Yuichi
    Akashi, Akimi
    Naoe, Tomoki
    Kiyoi, Hitoshi
    ONCOTARGET, 2016, 7 (30) : 47018 - 47032
  • [32] Targeted inhibition of FLT3 overcomes the block to myeloid differentiation in 32Dcl3 cells caused by expression of FLT3/ITD mutations
    Zheng, R
    Friedman, AD
    Small, D
    BLOOD, 2002, 100 (12) : 4154 - 4161
  • [33] Expression of FLT3/ITD mutations suppresses SHP-1.
    Chen, PL
    Allebach, J
    Small, D
    BLOOD, 2002, 100 (11) : 85A - 85A
  • [34] Developing dual FLT3/MNK inhibitors to overcome sorafenib resistance in FLT3-ITD AML cells
    Zhao, Linxiang
    Zuo, Shuwei
    Xing, Kun
    Yue, Xiaoshuang
    Zhang, Huimin
    Zhang, Jingyi
    Waxman, Samuel
    Jing, Yongkui
    CANCER RESEARCH, 2024, 84 (06)
  • [35] High FLT3 mRNA expression without FLT3-ITD in infants with acute myeloid leukernia
    Shimada, Akira
    Yamada, Miho
    Yamashita, Yuka
    Yokozawa, Toshiya
    Tomizawa, Daisuke
    Kinoshita, Akitoshi
    Taga, Takashi
    Tawa, Akio
    Taki, Tomohiko
    Hayashi, Yasuhide
    Fujimoto, Junichiro
    Horibe, Keizo
    Adachi, Souichi
    CANCER RESEARCH, 2012, 72
  • [36] Relation between FLT3 mutations, high flow cytometric FLT3 expression and CXCR4 expression in CD34+cells in adult acute myeloid leukemia
    Yang, Li
    Wu, Xiao Jin
    Wu, De Pei
    BLOOD, 2007, 110 (11) : 89B - 89B
  • [37] The FLT3 and Pim kinases inhibitor SGI-1776 preferentially target FLT3-ITD AML cells
    Hospital, Marie-Anne
    Green, Alexa S.
    Lacombe, Catherine
    Mayeux, Patrick
    Bouscary, Didier
    Tamburini, Jerome
    BLOOD, 2012, 119 (07) : 1791 - 1792
  • [38] CG′806, a First-in-Class FLT3/BTK Inhibitor, Exerts Superior Potency against AML Cells Harboring ITD, TKD and Gatekeeper Mutated FLT3 or Wild-Type FLT3
    Zhang, Weiguo
    Zhang, Hongying
    Local, Andrea
    Rice, Wiliam
    Ly, Charlie
    Yu, Guopan
    Howell, Stephen
    Andreeff, Michael
    CLINICAL LYMPHOMA MYELOMA & LEUKEMIA, 2017, 17 : S274 - S275
  • [39] FLT3, PIM and CXCR4 Expression In Acute Myeloid Leukemia
    Fernandez, Rafael Alonso
    Rapado, Inmaculada
    Nerea, Castro
    Martinez-Sanchez, Pilar
    Pena, Ascension
    Garcia-Alonso, Luis
    Rubio, Montserrat
    Rodriguez, Antonia
    Martinez-Barranco, Maria del Pilar
    Calle, Maria del Carmen
    Otero, Maria Jose
    Ponce, Juan Carlos
    Gilsanz-Rodriguez, Florida
    Ayala, Rosa M.
    Martinez-Lopez, Joaquin
    BLOOD, 2013, 122 (21)
  • [40] FLT3-ITD allelic ratio and HLF expression predict FLT3 inhibitor efficacy in adult AML
    Jarno Kivioja
    Disha Malani
    Ashwini Kumar
    Mika Kontro
    Alun Parsons
    Olli Kallioniemi
    Caroline A. Heckman
    Scientific Reports, 11