Closed-Loop Control of Epilepsy by Transcranial Electrical Stimulation

被引：336
|
作者：
Berenyi, Antal [1 ,2 ,3 ]
Belluscio, Mariano [1 ]
Mao, Dun [1 ]
Buzsaki, Gyoergy [1 ,2 ]
机构：
[1] Rutgers State Univ, Ctr Mol & Behav Neurosci, Newark, NJ 07102 USA
[2] NYU, Sch Med, Inst Neurosci, New York, NY 10016 USA
[3] Univ Szeged, Dept Physiol, H-6720 Szeged, Hungary
来源：
SCIENCE | 2012年 / 337卷 / 6095期
关键词：
DEEP BRAIN-STIMULATION; SLEEP; SPINDLES; MEMORY; SPIKE; RATS;
D O I：
10.1126/science.1223154
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Many neurological and psychiatric diseases are associated with clinically detectable, altered brain dynamics. The aberrant brain activity, in principle, can be restored through electrical stimulation. In epilepsies, abnormal patterns emerge intermittently, and therefore, a closed-loop feedback brain control that leaves other aspects of brain functions unaffected is desirable. Here, we demonstrate that seizure-triggered, feedback transcranial electrical stimulation (TES) can dramatically reduce spike-and-wave episodes in a rodent model of generalized epilepsy. Closed-loop TES can be an effective clinical tool to reduce pathological brain patterns in drug-resistant patients.
引用
收藏
页码：735 / 737
页数：3
相关论文
共 50 条
  • [21] Design of a novel closed-loop neural electrical stimulation system
    Feng, Zhouyan
    Chen, Dan
    Xiao, Qianjiang
    Yi Qi Yi Biao Xue Bao/Chinese Journal of Scientific Instrument, 2012, 33 (02): : 279 - 285
  • [22] Toward Closed-Loop Electrical Stimulation of Neuronal Systems: A Review
    Tanskanen, Jarno M. A.
    Ahtiainen, Annika
    Hyttinen, Jari A. K.
    BIOELECTRICITY, 2020, 2 (04): : 328 - 347
  • [23] A closed-loop electrical stimulation system for cardiac cell cultures
    Whittington, RH
    Giovangrandi, L
    Kovacs, GTA
    IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING, 2005, 52 (07) : 1261 - 1270
  • [24] Closed-loop transcranial electrical stimulation for inhibiting epileptic activity propagation: a whole-brain model study
    Yu, Ying
    Wang, Haodong
    Liu, Xiaotong
    Wang, Qingyun
    NONLINEAR DYNAMICS, 2024, 112 (23) : 21369 - 21387
  • [25] Closed-Loop Brain Stimulation
    Zrenner, Christoph
    Ziemann, Ulf
    BIOLOGICAL PSYCHIATRY, 2024, 95 (06) : 545 - 552
  • [26] The Benefits of Closed-Loop Transcranial Alternating Current Stimulation on Subjective Sleep Quality
    Robinson, Charles S. H.
    Bryant, Natalie B.
    Maxwell, Joshua W.
    Jones, Aaron P.
    Robert, Bradley
    Lamphere, Melanie
    Combs, Angela
    Al Azzawi, Hussein M.
    Gibson, Benjamin C.
    Sanguinetti, Joseph L.
    Ketz, Nicholas A.
    Pilly, Praveen K.
    Clark, Vincent P.
    BRAIN SCIENCES, 2018, 8 (12):
  • [27] Online Learning Koopman Operator for Closed-Loop Electrical Neurostimulation in Epilepsy
    Liang, Zhichao
    Luo, Zixiang
    Liu, Keyin
    Qiu, Jingwei
    Liu, Quanying
    IEEE JOURNAL OF BIOMEDICAL AND HEALTH INFORMATICS, 2023, 27 (01) : 492 - 503
  • [28] Online Learning Koopman operator for closed-loop electrical neurostimulation in epilepsy
    Liang, Zhichao
    Luo, Zixiang
    Liu, Keyin
    Qiu, Jingwei
    Liu, Quanying
    arXiv, 2021,
  • [29] EVALUATION OF CLOSED-LOOP CONTROL SYSTEM FOR RESTORING STANDING AND SITTING FUNCTIONS BY FUNCTIONAL ELECTRICAL STIMULATION
    Liu, Cheng-Liang
    Yu, Chung-Huang
    Chen, Shih-Ching
    Chen, Chang-Hung
    BIOMEDICAL ENGINEERING-APPLICATIONS BASIS COMMUNICATIONS, 2005, 17 (01): : 19 - 26
  • [30] Optimization of closed-loop electrical stimulation enables robust cerebellar-directed seizure control
    Stieve, Bethany J.
    Richner, Thomas J.
    Krook-Magnuson, Chris
    Netoff, Theoden, I
    Krook-Magnuson, Esther
    BRAIN, 2023, 146 (01) : 91 - 108
12345