Closed-Loop Control of Epilepsy by Transcranial Electrical Stimulation

被引：336
|
作者：
Berenyi, Antal [1 ,2 ,3 ]
Belluscio, Mariano [1 ]
Mao, Dun [1 ]
Buzsaki, Gyoergy [1 ,2 ]
机构：
[1] Rutgers State Univ, Ctr Mol & Behav Neurosci, Newark, NJ 07102 USA
[2] NYU, Sch Med, Inst Neurosci, New York, NY 10016 USA
[3] Univ Szeged, Dept Physiol, H-6720 Szeged, Hungary
来源：
SCIENCE | 2012年 / 337卷 / 6095期
关键词：
DEEP BRAIN-STIMULATION; SLEEP; SPINDLES; MEMORY; SPIKE; RATS;
D O I：
10.1126/science.1223154
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Many neurological and psychiatric diseases are associated with clinically detectable, altered brain dynamics. The aberrant brain activity, in principle, can be restored through electrical stimulation. In epilepsies, abnormal patterns emerge intermittently, and therefore, a closed-loop feedback brain control that leaves other aspects of brain functions unaffected is desirable. Here, we demonstrate that seizure-triggered, feedback transcranial electrical stimulation (TES) can dramatically reduce spike-and-wave episodes in a rodent model of generalized epilepsy. Closed-loop TES can be an effective clinical tool to reduce pathological brain patterns in drug-resistant patients.
引用
收藏
页码：735 / 737
页数：3
相关论文
共 50 条
  • [1] Closed-loop stimulation in the control of focal epilepsy
    Smith, J
    Murro, M
    Politsky, J
    Park, Y
    Fountas, K
    Jenkins, P
    Greene, D
    Esteller, R
    PROCEEDINGS OF THE 14TH MEETING OF THE WORLD SOCIETY OF STEREOTACTIC AND FUNCTIONAL NEUROSURGERY WSSFN, 2005, : 73 - 78
  • [2] PyTES: A Python']Python toolbox for closed-loop transcranial electrical stimulation
    Xu, Jiachen
    Grosse-Wentrup, Moritz
    SOFTWAREX, 2023, 23
  • [3] Neocortical electrical stimulation for epilepsy: Closed-loop versus open-loop
    Vassileva, Albena
    van Blooijs, Dorien
    Leijten, Frans
    Huiskamp, Geertjan
    EPILEPSY RESEARCH, 2018, 141 : 95 - 101
  • [4] Closed-Loop Stimulation in the Control of Focal Epilepsy of Insular Origin
    Smith, Joseph R.
    Fountas, Kostas N.
    Murro, Anthony M.
    Park, Yong D.
    Jenkins, Patrick D.
    Morrell, Martha
    Esteller, Rosanna
    Greene, David
    STEREOTACTIC AND FUNCTIONAL NEUROSURGERY, 2010, 88 (05) : 281 - 287
  • [5] Closed loop stimulation for epilepsy therapy ["Closed-loop"-stimulation zur epilepsietherapie]
    Schulze-Bonhage A.
    Somerlik K.
    Duempelmann M.
    Zeitschrift für Epileptologie, 2014, 27 (1): : 55 - 59
  • [6] A Programmable Wireless EEG Monitoring SoC with Open/Closed-Loop Optogenetic and Electrical Stimulation for Epilepsy Control
    Lee, Shuenn-Yuh
    Tsou, Chieh
    Huang, Peng-Wei
    Cheng, Po-Hao
    Liao, Chi-Chung
    Liao, Zhan-Xien
    Lee, Hao-Yun
    Lin, Chou-Ching
    Hsieh, Chia-Hsiang
    2019 IEEE INTERNATIONAL SOLID-STATE CIRCUITS CONFERENCE (ISSCC), 2019, 62 : 372 - +
  • [7] Closed-loop control of the heart rate by electrical stimulation of the vagus nerve
    Marco Tosato
    Ken Yoshida
    Egon Toft
    Vitas Nekrasas
    Johannes J. Struijk
    Medical and Biological Engineering and Computing, 2006, 44 : 161 - 169
  • [8] CLOSED-LOOP CONTROL OF FORCE DURING ELECTRICAL-STIMULATION OF MUSCLE
    CRAGO, PE
    MORTIMER, JT
    PECKHAM, PH
    IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING, 1980, 27 (06) : 306 - 311
  • [9] Closed-loop control of the heart rate by electrical stimulation of the vagus nerve
    Tosato, Marco
    Yoshida, Ken
    Toft, Egon
    Nekrasas, Vitas
    Struijk, Johannes J.
    MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING, 2006, 44 (03) : 161 - 169
  • [10] Automated search of stimulation targets with closed-loop transcranial magnetic stimulation
    Tervo, Aino E.
    Metsomaa, Johanna
    Nieminen, Jaakko O.
    Sarvas, Jukka
    Ilmoniemi, Risto J.
    NEUROIMAGE, 2020, 220
12345