Activity of some platinum(II/IV) complexes with edda-type ligands against human adenocarcinoma HeLa cells

被引：15
|
作者：
Kaluderovic, Goran N.
Dinovic, Vesna M.
Juranic, Zorica D.
Stanojkovic, Tatjana P.
Sabo, Tibor J.
机构：
[1] Univ Belgrade, Fac Chem, Belgrade 11001, Serbia Monteneg
[2] Inst Oncol & Radiol, Belgrade 11000, Serbia Monteneg
来源：
JOURNAL OF COORDINATION CHEMISTRY | 2006年 / 59卷 / 07期
关键词：
platinum(IV); platinum(II); edda; adenocarcinoma HeLa; cytotoxicity;
D O I：
10.1080/00958970500404708
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
Cisplatin analogues, cis-dichloro(ethylenediamine-N,N'-di-3-propanoic acid)platinum(II) (1) and cis-iodo(ethylenediamine-N,N'-di-3-propanoic acid) platinum(II) (2), as well as trans-dichloro(ethylenediamine-N,N'-di-3-propanoato)platinum(IV) (3), trans-dibromo(ethylenediamine-N,N'-di-3-propanoato)platinum(IV) (4), trans-dichloro(propylenediamine-N,N'-diacetato)platinum(IV) (5) and trans-dibromo(propylenediamine-N,N'-diacetato)platinum(IV) (6), -([Pt(H(2)eddp)Cl(2)], [Pt(Heddp)I], trans-[Pt(eddp)Cl(2)], trans-[Pt(eddp)Br(2)], trans-[Pt(pdda)Cl(2)] and trans-[Pt(pdda)Br(2)], respectively) were used to assess antitumor selectivity against human adenocarcinoma HeLa cells. The results show that different oxidation states of platinum, different halide ligands, chelating aminocarboxylato and diamine backbones have similar effects with edda-type ligands and activity is lower than for cisplatin.
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收藏
页码：815 / 819
页数：5
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