CYTOTOXIC ACTIVITY STUDIES OF SOME PLATINUM(II) COMPLEXES WITH 2-SUBSTITUTEDBENZIMIDAZOLE LIGANDS

被引：1

作者：

Ozcelik, Azime Berna ^{[1
]}

Gumus, Fatma ^{[1
]}

Kilic Suloglu, Aysun ^{[2
]}

Selmanoglu, Guldeniz ^{[2
]}

机构：

[1] Gazi Univ, Fac Pharm, Dept Pharmaceut Chem, TR-06330 Ankara, Turkey

[2] Hacettepe Univ, Fac Sci, Dept Biol, TR-06800 Ankara, Turkey

来源：

REVUE ROUMAINE DE CHIMIE | 2019年 / 64卷 / 09期

关键词：

benzimidazole; platinum complexes; cytotoxic activity; HeLa cell line; MCF-7 cell line; ANTIMICROBIAL ACTIVITY; DNA INTERACTIONS; BENZIMIDAZOLE; DERIVATIVES; BINDING; SPECTRA; ACID;

D O I：

10.33224/rrch.2019.64.9.10

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In the present study, two Pt( II) complexes with 2-substitutedbenzimida-zole ligands were synthesized and evaluated for their in vitro cytotoxic activities on HeLa and MCF-7 cell lines. 3-[4,5-dimethylthiazole-2-yl]-2,5-diphenyltetrazolium bromide (MTT) test results showed that complex 2 which was found to be the more active than carboplatin was the most cytotoxic active compound against the HeLa and MCF-7 cell lines among the tested compounds.

引用

页码：829 / 834

页数：6

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