Improved Synthesis of 2-(1-Adamantyl)-4-bromophenol and 2-(1-Adamantyl)-4-bromoanisole, Intermediates in Adapalene Synthesis

被引：1
|
作者：
Sokolenko, V. A. [1 ]
Svirskaya, N. M. [1 ]
Peterson, I. V. [1 ]
Rubailo, A. I. [1 ,2 ]
机构：
[1] Russian Acad Sci, Siberian Branch, Inst Chem & Chem Technol, Krasnoyarsk 660036, Russia
[2] Siberian Fed Univ, Krasnoyarsk 660041, Russia
来源：
PHARMACEUTICAL CHEMISTRY JOURNAL | 2013年 / 47卷 / 04期
关键词：
adapalene; 6-[3-(1-adamantyl)-4-methoxyphenyl]-2-naphthoic acid; 2-(1-adamantyl)-4-bromophenol; 2-(1-adamantyl)-4-bromoanisole; 1-adamantanol; 1-bromoadamantane; synthesis; alkylation;
D O I：
10.1007/s11094-013-0931-4
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A new simple and environmentally friendly synthetic method for 2-(1-adamantyl)-4-bromophenol that did not use catalysts and solvents was developed. A new simplified preparation method for 2-(1-adamantyl)-4-bromoanisole in one step instead of two was proposed. Both compounds are intermediates in the first and second synthetic steps to 6-[3-(1-adamantyl)-4-methoxyphenyl]-2-naphthoic acid (adapalene).
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页码：217 / 218
页数：2
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