Synthesis of benzimidazoles by Cu2O-catalyzed cascade reactions between o-haloaniline and amidine hydrochlorides

被引：33
|
作者：
Qu, Yanyang [1 ]
Pan, Lei [1 ]
Wu, Zhiqing [1 ]
Zhou, Xiangge [1 ]
机构：
[1] Sichuan Univ, Coll Chem, Inst Homogeneous Catalysis, Chengdu 610064, Peoples R China
来源：
TETRAHEDRON | 2013年 / 69卷 / 06期
关键词：
Copper; Catalysis; Cyclization; Heterocycle; Benzimidazole; COPPER-CATALYZED SYNTHESIS; ONE-POT SYNTHESIS; COUPLING REACTIONS; PHASE SYNTHESIS; LIGANDS; ULLMANN;
D O I：
10.1016/j.tet.2012.12.039
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient Cu2O-catalyzed method for the synthesis of benzimidazole derivatives from amidine hydrochlorides and o-haloaniline has been developed. The cascade C-N coupling and intramolecular transamination reaction provided benzimidazole derivatives in high yields up to 90%. (C) 2012 Elsevier Ltd. All rights reserved.
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页码：1717 / 1719
页数：3
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