Efficient palladium-catalyzed synthesis of substituted indoles employing a new (silanyloxyphenyl)phosphine ligand

被引：30

作者：

Lavery, Christopher B. ^{[1
]}

McDonald, Robert ^{[2
]}

Stradiotto, Mark ^{[1
]}

机构：

[1] Dalhousie Univ, Dept Chem, Halifax, NS B3H 4R2, Canada

[2] Univ Alberta, Dept Chem, Xray Crystallog Lab, Edmonton, AB T6G 2G2, Canada

来源：

CHEMICAL COMMUNICATIONS | 2012年 / 48卷 / 58期

基金：

加拿大自然科学与工程研究理事会;

关键词：

CROSS-COUPLING REACTIONS; BUCHWALD-HARTWIG AMINATION; ARYL CHLORIDES; AMINES; HETEROCYCLES; ARYLATION; CYCLIZATION; POTASSIUM; TOSYLATES; DALPHOS;

D O I：

10.1039/c2cc33071g

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The new and easily prepared OTips-DalPhos ligand (L1) offers broad substrate scope at relatively low loadings in the palladium-catalyzed C-N cross-coupling/cyclization of o-alkynylhalo(hetero)arenes with primary amines, affording indoles and related heterocyclic derivatives in high yield.

引用

页码：7277 / 7279

页数：3

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