Possible Therapeutic Application of Targeting Type II Natural Killer T Cell-Mediated Suppression of Tumor immunity

被引：16
|
作者：
Kato, Shingo [1 ]
Berzofsky, Jay A. [2 ]
Terabe, Masaki [2 ]
机构：
[1] Yokohama City Univ, Sch Med, Dept Gastroenterol & Hepatol, Yokohama, Kanagawa, Japan
[2] NCI, Mol Immunogenet & Vaccine Res Sect, Vaccine Branch, Ctr Canc Res,NIH, Bethesda, MD 20892 USA
来源：
FRONTIERS IN IMMUNOLOGY | 2018年 / 9卷
关键词：
natural killer T cell; type II natural killer T cell; tumor immunology; immune regulation; immunosuppression; immunotherapy; lipid antigens; transforming growth factor beta; GROWTH-FACTOR-BETA; INVARIANT NKT CELLS; CHRONIC LYMPHOCYTIC-LEUKEMIA; INFLAMMATORY-LIVER-DISEASE; GAUCHER-DISEASE; CD1D EXPRESSION; ADIPOSE-TISSUE; ALPHA-GALACTOSYLCERAMIDE; MONOCLONAL-ANTIBODY; ULCERATIVE-COLITIS;
D O I：
10.3389/fimmu.2018.00314
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Natural killer T (NKT) cells are a unique T cell subset that exhibits characteristics from both the innate immune cells and T cells. There are at least two subsets of NKT cells, type I and type II. These two subsets of NKT cells have opposite functions in antitumor immunity. Type I NKT cells usually enhance and type II NKT cells suppress antitumor immunity. In addition, these two subsets of NKT cells cross-regulate each other. In this review, we mainly focus on immunosuppressive NKT cells, type II NKT cells. After summarizing their definition, experimental tools to study them, and subsets of them, we will discuss possible therapeutic applications of type II NKT cell pathway targeted therapies.
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页数：10
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