Possible Therapeutic Application of Targeting Type II Natural Killer T Cell-Mediated Suppression of Tumor immunity

被引:16
|
作者
Kato, Shingo [1 ]
Berzofsky, Jay A. [2 ]
Terabe, Masaki [2 ]
机构
[1] Yokohama City Univ, Sch Med, Dept Gastroenterol & Hepatol, Yokohama, Kanagawa, Japan
[2] NCI, Mol Immunogenet & Vaccine Res Sect, Vaccine Branch, Ctr Canc Res,NIH, Bethesda, MD 20892 USA
来源
FRONTIERS IN IMMUNOLOGY | 2018年 / 9卷
关键词
natural killer T cell; type II natural killer T cell; tumor immunology; immune regulation; immunosuppression; immunotherapy; lipid antigens; transforming growth factor beta; GROWTH-FACTOR-BETA; INVARIANT NKT CELLS; CHRONIC LYMPHOCYTIC-LEUKEMIA; INFLAMMATORY-LIVER-DISEASE; GAUCHER-DISEASE; CD1D EXPRESSION; ADIPOSE-TISSUE; ALPHA-GALACTOSYLCERAMIDE; MONOCLONAL-ANTIBODY; ULCERATIVE-COLITIS;
D O I
10.3389/fimmu.2018.00314
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Natural killer T (NKT) cells are a unique T cell subset that exhibits characteristics from both the innate immune cells and T cells. There are at least two subsets of NKT cells, type I and type II. These two subsets of NKT cells have opposite functions in antitumor immunity. Type I NKT cells usually enhance and type II NKT cells suppress antitumor immunity. In addition, these two subsets of NKT cells cross-regulate each other. In this review, we mainly focus on immunosuppressive NKT cells, type II NKT cells. After summarizing their definition, experimental tools to study them, and subsets of them, we will discuss possible therapeutic applications of type II NKT cell pathway targeted therapies.
引用
收藏
页数:10
相关论文
共 50 条
  • [1] T cell-mediated suppression of angiogenesis results in tumor protective immunity
    Zhou, H
    Luo, YP
    Mizutani, M
    Mizutani, N
    Reisfeld, RA
    Xiang, R
    BLOOD, 2005, 106 (06) : 2026 - 2032
  • [2] The NKC and regulation of natural killer cell-mediated immunity
    Brown, MG
    Scalzo, AA
    Yokoyama, WM
    MAJOR HISTOCOMPATIBILITY COMPLEX: EVOLUTION, STRUCTURE AND FUNCTION, 2000, : 287 - 301
  • [3] The critical role of the tumor microenvironment in shaping natural killer cell-mediated anti-tumor immunity
    Baginska, Joanna
    Viry, Elodie
    Paggetti, Jerome
    Medves, Sandrine
    Berchem, Guy
    Moussay, Etienne
    Janji, Bassam
    FRONTIERS IN IMMUNOLOGY, 2013, 4
  • [4] Activated natural killer cell-mediated immunity is required for the inhibition of tumor metastasis by dendritic cell vaccination
    Kim, A
    Noh, YW
    Kim, KD
    Jang, YS
    Choe, YK
    Lim, JS
    EXPERIMENTAL AND MOLECULAR MEDICINE, 2004, 36 (05): : 428 - 443
  • [5] Activated natural killer cell-mediated immunity is required for the inhibition of tumor metastasis by dendritic cell vaccination
    Aeyung Kim
    Young-Woock Noh
    Kwang Dong Kim
    Yong Suk Jang
    Yong-Kyung Choe
    Jong-Seok Lim
    Experimental & Molecular Medicine, 2004, 36 : 428 - 443
  • [6] Strain differences in natural killer cell-mediated immunity among mice: A possible mechanism for the low natural killer cell activity of A/J mice
    Whyte, AL
    Miller, SC
    IMMUNOBIOLOGY, 1998, 199 (01) : 23 - 38
  • [7] SUPPRESSION OF CELL-MEDIATED TUMOR IMMUNITY BY CORYNEBACTERIUM-PARVUM
    KIRCHNER, H
    GLASER, M
    HERBERMAN, RB
    NATURE, 1975, 257 (5525) : 396 - 398
  • [8] VIRAL ENHANCEMENT OF T CELL-MEDIATED TUMOR IMMUNITY
    REINISCH, CL
    BOCHNER, S
    FEDERATION PROCEEDINGS, 1975, 34 (03) : 974 - 974
  • [9] From sabotage to camouflage: viral evasion of cytotoxic T lymphocyte and natural killer cell-mediated immunity
    Farrell, HE
    Davis-Poynter, NJ
    SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, 1998, 9 (03) : 369 - 378
  • [10] Intravenous administration of BCG in mice promotes natural killer and T cell-mediated antitumor immunity in the lung
    Moreo, Eduardo
    Jarit-Cabanillas, Aitor
    Robles-Vera, Inaki
    Uranga, Santiago
    Guerrero, Claudia
    Gomez, Ana Belen
    Mata-Martinez, Pablo
    Minute, Luna
    Araujo-Voces, Miguel
    Felgueres, Maria Jose
    Esteso, Gloria
    Uranga-Murillo, Iratxe
    Arias, Maykel
    Pardo, Julian
    Martin, Carlos
    Vales-Gomez, Mar
    del Fresno, Carlos
    Sancho, David
    Aguilo, Nacho
    NATURE COMMUNICATIONS, 2023, 14 (01)