In vitro and in vivo inhibition of LPS-induced tumor necrosis factor-α production by dimeric gallotannin analogues

被引：7
|
作者：
Feldman, KS [1 ]
Wilson, SL
Lawlor, MD
Lang, CH
Scheuchenzuber, WJ
机构：
[1] Penn State Univ, Dept Chem, University Pk, PA 16802 USA
[2] Penn State Univ, Coll Med, Dept Cellular & Mol Physiol, Hershey, PA 17033 USA
[3] Penn State Univ, Life Sci Consortium, University Pk, PA 16802 USA
来源：
BIOORGANIC & MEDICINAL CHEMISTRY | 2002年 / 10卷 / 01期
关键词：
D O I：
10.1016/S0968-0896(01)00251-6
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Designed dimeric gallotannin analogues featuring two tetragalloylglucopyranose cores connected by various hydrocarbon linkers inhibit tumor necrosis factor-alpha secretion from lipopolysaccharide-stimulated human peripheral blood mononuclear cells by up to 53% (5-24 muM concentration range) compared to control. Comparable suppression of tumor necrosis factor-alpha levels (similar to 50% vs control) was observed in the plasma of rats co-treated with lipopolysaccharide and specific tannin analogues selected for their lack of interleukin 1-beta stimulating activity. (C) 2001 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：47 / 55
页数：9
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