Isolation and Characterization of Low-Molecular-Weight Chromium-binding Substance (LMWCr) from Chicken Liver

被引：8
|
作者：
Viera, Margarita [1 ]
Davis-McGibony, C. Michele [1 ]
机构：
[1] Georgia So Univ, Dept Chem, Statesboro, GA 30460 USA
来源：
PROTEIN JOURNAL | 2008年 / 27卷 / 06期
关键词：
Chromium; Chicken; Low-molecular-weight chromium-binding substance; Chromodulin;
D O I：
10.1007/s10930-008-9146-z
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Chromodulin (also known as low-molecular-weight chromium-binding substance, LMWCr) is a chromium-binding oligopeptide proposed to play a role in insulin signaling and chromium transport in mammals. This laboratory has isolated and purified this material from a non-mammalian source, an avian. Spectroscopic and physical characterization of the isolated material suggests the material is an oligopeptide with a multinuclear chromium assembly bridged via asparatate and glutamate residues very similar to its mammalian counterparts. The isolated material also possesses a biological activity similar to other LMWCr isolates.
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页码：371 / 375
页数：5
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