A practical synthesis of 2-aryl-indole-6-carboxylic acids

被引：7
|
作者：
Gallou, F
Yee, N
Qiu, FH
Senanayake, C
Linz, G
Schnaubelt, J
Soyka, R
机构：
[1] Boehringer Ingelheim Pharmaceut Inc, Dept Chem Dev, Ridgefield, CT 06877 USA
[2] Boehringer Ingelheim Pharma GmbH & Co KG, Dept Chem Dev, D-88397 Biberach, Germany
来源：
SYNLETT | 2004年 / 05期
关键词：
indole; S(N)Ar reaction; reductive cyclization;
D O I：
10.1055/s-2004-820015
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A practical synthesis of 2-aryl-indole-6-carboxylic acids was developed via a sequence consisting of S(N)Ar reaction, reductive cyclization, hydrolysis and decarboxylation. This process is efficient in terms of operational simplicity, cost effectiveness and is amenable to large scale production.
引用
收藏
页码：883 / 885
页数：3
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