Regulation of DNA Replication Licensing

被引：1
|
作者：
Niida, Hiroyuki [1 ]
Kitagawa, Masatoshi [1 ]
机构：
[1] Hamamatsu Univ Sch Med, Dept Mol Biol, Higashi Ku, Hamamatsu, Shizuoka 4313192, Japan
来源：
CURRENT DRUG TARGETS | 2012年 / 13卷 / 13期
关键词：
CDC10-dependent transcript 1 (CDT1); cell division cycle 6 (CDC6); DNA replication; high mobility group AT-hook 1 (HMGA1); histone acetyltransferase binding to ORC (HBO1); homeobox protein Hox-D13 (HOXD13); licensing; mini chromosome maintenance (MCM); origin recognition complex (ORC); prereplication complex (pre-RC); ORIGIN RECOGNITION COMPLEX; HBO1 HISTONE ACETYLASE; CELL-CYCLE; SUBCELLULAR-LOCALIZATION; PREREPLICATION COMPLEXES; ACETYLTRANSFERASE HBO1; ATP HYDROLYSIS; MAMMALIAN CDC6; FACTOR CDT1; PHOSPHORYLATION;
D O I：
10.2174/138945012803529965
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
In eukaryotic cells, DNA replication is tightly regulated to occur only once per cell cycle. DNA licensing is a mechanism to guarantee this aim; that is, licensing of replication initiation is permitted during late M phase to G1 phase. The license is canceled by the start of DNA replication. Once DNA replication begins, the license is never given until the next late M phase. The licensing corresponds to the process of assembling components of the pre-replication complex (pre-RC) on the replication origin DNA. This pre-RC is the target of several different regulation systems to prevent re-replication of DNA during a single cell cycle. In this review, the regulation mechanisms mainly in mammals to control assembling components of the pre-RC will be discussed.
引用
收藏
页码：1588 / 1592
页数：5
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