Regulation of DNA Replication Licensing

被引：1

作者：

Niida, Hiroyuki ^{[1
]}

Kitagawa, Masatoshi ^{[1
]}

机构：

[1] Hamamatsu Univ Sch Med, Dept Mol Biol, Higashi Ku, Hamamatsu, Shizuoka 4313192, Japan

来源：

CURRENT DRUG TARGETS | 2012年 / 13卷 / 13期

关键词：

CDC10-dependent transcript 1 (CDT1); cell division cycle 6 (CDC6); DNA replication; high mobility group AT-hook 1 (HMGA1); histone acetyltransferase binding to ORC (HBO1); homeobox protein Hox-D13 (HOXD13); licensing; mini chromosome maintenance (MCM); origin recognition complex (ORC); prereplication complex (pre-RC); ORIGIN RECOGNITION COMPLEX; HBO1 HISTONE ACETYLASE; CELL-CYCLE; SUBCELLULAR-LOCALIZATION; PREREPLICATION COMPLEXES; ACETYLTRANSFERASE HBO1; ATP HYDROLYSIS; MAMMALIAN CDC6; FACTOR CDT1; PHOSPHORYLATION;

D O I：

10.2174/138945012803529965

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

In eukaryotic cells, DNA replication is tightly regulated to occur only once per cell cycle. DNA licensing is a mechanism to guarantee this aim; that is, licensing of replication initiation is permitted during late M phase to G1 phase. The license is canceled by the start of DNA replication. Once DNA replication begins, the license is never given until the next late M phase. The licensing corresponds to the process of assembling components of the pre-replication complex (pre-RC) on the replication origin DNA. This pre-RC is the target of several different regulation systems to prevent re-replication of DNA during a single cell cycle. In this review, the regulation mechanisms mainly in mammals to control assembling components of the pre-RC will be discussed.

引用

页码：1588 / 1592

页数：5

共 50 条

[1] Regulation of DNA Replication Licensing and Re-Replication by Cdt1
Zhang, Hui
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2021, 22 (10)
[2] DNA replication licensing
Nishitani, H
Lygerou, Z
FRONTIERS IN BIOSCIENCE-LANDMARK, 2004, 9 : 2115 - 2132
[3] Investigating the regulation of DNA replication origin licensing during cellular quiescence
Coleman, Kate Elizabeth
Yan, Feng
Major, Ben
Cook, Jeanette Gowen
FASEB JOURNAL, 2013, 27
[4] The DNA replication licensing system
Thommes, P
Blow, JJ
CANCER SURVEYS, 1997, 29 : 75 - 90
[5] DNA Replication: Rethinking origin licensing
Bell, Stephen P.
ELIFE, 2017, 6
[6] Transcriptional control of DNA replication licensing by Myc
Taras Valovka
Manuela Schönfeld
Philipp Raffeiner
Kathrin Breuker
Theresia Dunzendorfer-Matt
Markus Hartl
Klaus Bister
Scientific Reports, 3
[7] Reconstitution of DNA replication licensing on the chromatin fiber
Hizume, K.
Yagura, M.
Araki, H.
MOLECULAR BIOLOGY OF THE CELL, 2012, 23
[8] DNA replication licensing control and rereplication prevention
Li, Chonghua
Jin, Jianping
PROTEIN & CELL, 2010, 1 (03) : 227 - 236
[9] Control of DNA replication licensing in a cell cycle
Nishitani, H
Lygerou, Z
GENES TO CELLS, 2002, 7 (06) : 523 - 534
[10] DNA replication licensing in somatic and germ cells
Eward, KL
Obermann, EC
Shreeram, S
Loddo, M
Fanshawe, T
Williams, C
Jung, HI
Prevost, AT
Blow, JJ
Stoeber, K
Williams, GH
JOURNAL OF CELL SCIENCE, 2004, 117 (24) : 5875 - 5886

← 1 2 3 4 5 →