Antidopaminergic Activity of Vitex negundo (Linn) Roots

被引：0

作者：

Borse, L. B. ^{[2
]}

Muthu, A. Kottai ^{[1
]}

Thangatripathi, A. ^{[3
]}

Borse, S. L. ^{[4
]}

机构：

[1] Annamalai Univ, Dept Pharm, Annamalainagar 608002, Tamil Nadu, India

[2] Karpagam Univ, Dept Pharmacol, Coimbatore 641021, Tamil Nadu, India

[3] Sankaralingam Bhuvaneswari Coll Pharm, Sivakasi 626130, India

[4] PSGVP Mandals Coll Pharm, Shahada 425409, India

来源：

ASIAN JOURNAL OF CHEMISTRY | 2012年 / 24卷 / 07期

关键词：

Antidopaminergic; Vitex negundo; Dopamine; Amphetamine; Haloperidol; EXTRACT; L;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The objective of the study was to investigate the effect of acetone soluble fraction of methanolic extract of roots of the vitex negundo on dopaminergic function. The effect of acetone soluble fraction of methanolic extract of roots of the Vitex negundo (50 and 100 mg/kg, i.p.) was studied on haloperidol-induced catalepsy in mice, amphetamine induced stereotyped behaviour in rats and dopamine-induced contraction isolated vas deferens preparation of rat. The acetone soluble fraction of methanolic extract of isolated of V negundo significantly potentiated haloperidol induced catalepsy, antagonized dose dependant amphetamine-induced stereotyped behaviour and also antagonized dopamine induced contractions of rat vas deference. The result suggests that the methanolic extract of Vitex negundo possessed antidopaminergic principle.

引用

页码：3171 / 3173

页数：3

共 50 条

[21] Antioxidant and Antiinflammatory Activity of Vitex negundo
Kulkarni, R. R.
Virkar, A. D.
D'Mello, Priscilla
[J]. INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2008, 70 (06) : 838 - 840
[22] CHEMICAL-CONSTITUENTS OF DILLENIA-INDICA LINN AND VITEX-NEGUNDO LINN
MUKHERJEE, KS
BADRUDDOZA, S
[J]. JOURNAL OF THE INDIAN CHEMICAL SOCIETY, 1981, 58 (01) : 97 - 98
[23] Insight into the bronchodilator activity of Vitex negundo
Khan, Munasib
Shah, Abdul Jabbar
Gilani, Anwarul Hassan
[J]. PHARMACEUTICAL BIOLOGY, 2015, 53 (03) : 340 - 344
[24] Antibacterial properties of plant extract of Vitex negundo Linn. (Verbenaceae)
Samidurai, K.
Jebanesan, A.
Saravankumar, A.
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES INDIA SECTION B-BIOLOGICAL SCIENCES, 2010, 80 : 174 - 176
[25] A Prospective Review on Phyto-pharmacological Aspects of Vitex negundo Linn
Khan, Mohd Faisal
Arora, Poonam
Dhobi, Mahaveer
[J]. CURRENT TRADITIONAL MEDICINE, 2021, 7 (01) : 138 - 150
[26] Potential of Vitex negundo roots in the treatment of ulcerative colitis in mice
Zaware, Bharati B.
Nirmal, Sunil A.
Baheti, D. G.
Patil, Anuja N.
Mandal, Subhash C.
[J]. PHARMACEUTICAL BIOLOGY, 2011, 49 (08) : 874 - 878
[27] ANTI-INFLAMMATORY EFFECTS OF LUTEOLIN, AN ACTIVE PRINCIPLE OF VITEX NEGUNDO LINN
Jamaludin, F. B.
Shaari, K.
Ali, R. Mat
Ali, D. A. I.
Pisar, M.
Lajis, N.
[J]. INFLAMMATION RESEARCH, 2011, 60 : 277 - 277
[28] Essential Oil Composition and Antibacterial Studies of Vitex negundo Linn. Extracts
Khokra, S. L.
Prakash, O.
Jain, S.
Aneja, K. R.
Dhingra, Yogita
[J]. INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2008, 70 (04) : 522 - 526
[29] EFFECTS OF LEAF EXTRACT OF VITEX-NEGUNDO ON LATHYRUS-SATIVUS LINN
RAHMAN, MS
BHATTACHARYA, GN
[J]. CURRENT SCIENCE, 1982, 51 (08): : 434 - 435
[30] Hepatoprotective Activity on Vitex negundo Linn. (Verbenaceae) by using Wistar Albino Rats in Ibuprofen Induced Model
Mahalakshmi, R.
Rajesh, P.
Ramesh, N.
Balasubramanian, V.
Kalman, V. Rajesh
[J]. INTERNATIONAL JOURNAL OF PHARMACOLOGY, 2010, 6 (05) : 658 - 663

← 1 2 3 4 5 →