Quantitative prediction of oral drug interactions caused by CYP3A4 inhibition for an extended panel of substrates and inhibitors

被引:0
|
作者
Loue, C. [1 ]
Tod, M. [2 ]
机构
[1] Hop Croix Rousse, F-69317 Lyon, France
[2] Univ Lyon 1, F-69365 Lyon, France
关键词
drug-drug interaction; cyp3a4; quantitative prediction; pharmacokinetics;
D O I
暂无
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
引用
收藏
页码:21 / 21
页数:1
相关论文
共 50 条
  • [31] Development of a Generalized, Quantitative Physicochemical Model of CYP3A4 Inhibition for Use in Early Drug Discovery
    R. J. Riley
    A. J. Parker
    S. Trigg
    C. N. Manners
    [J]. Pharmaceutical Research, 2001, 18 : 652 - 655
  • [32] Prediction of time-dependent CYP3A4 drug-drug interactions: Impact of enzyme degradation, parallel elimination pathways, and intestinal inhibition
    Galetin, A
    Burt, H
    Gibbons, L
    Houston, JB
    [J]. DRUG METABOLISM AND DISPOSITION, 2006, 34 (01) : 166 - 175
  • [33] Balancing oral exposure with Cyp3A4 inhibition in benzimidazole-based IGF-IR inhibitors
    Zimmermann, Kurt
    Wittman, Mark D.
    Saulnier, Mark G.
    Velaparthi, Upender
    Langley, David R.
    Sang, Xiaopeng
    Frennesson, David
    Carboni, Joan
    Li, Aixin
    Greer, Ann
    Gottardis, Marco
    Attar, Ricardo M.
    Yang, Zheng
    Balimane, Praveen
    Discenza, Lorell N.
    Vyas, Dolatrai
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2008, 18 (14) : 4075 - 4080
  • [34] Pregnane X Receptor: Prediction and Attenuation of Human CYP3A4 Enzyme Induction and Drug-Drug Interactions
    Sinz, Michael W.
    [J]. ANNUAL REPORTS IN MEDICINAL CHEMISTRY, VOL 43, 2008, 43 : 405 - 418
  • [35] Effects of drug-drug interactions and CYP3A4 variants on alectinib metabolism
    Ya-nan Liu
    Jie Chen
    Jing Wang
    Qingqing Li
    Guo-xin Hu
    Jian-ping Cai
    Guanyang Lin
    Ren-ai Xu
    [J]. Archives of Toxicology, 2023, 97 : 2133 - 2142
  • [36] Effects of drug-drug interactions and CYP3A4 variants on alectinib metabolism
    Liu, Ya-nan
    Chen, Jie
    Wang, Jing
    Li, Qingqing
    Hu, Guo-xin
    Cai, Jian-ping
    Lin, Guanyang
    Xu, Ren-ai
    [J]. ARCHIVES OF TOXICOLOGY, 2023, 97 (08) : 2133 - 2142
  • [37] Midazolam as a Probe for Heterotropic Drug-Drug Interactions Mediated by CYP3A4
    Denisov, Ilia G.
    Grinkova, Yelena V.
    McLean, Mark A.
    Camp, Tyler
    Sligar, Stephen G.
    [J]. BIOMOLECULES, 2022, 12 (06)
  • [38] Evidence of potential pro-haemorrhagic drug interactions between CYP3A4 inhibitors and direct oral anticoagulants: Analysis of the FAERS database
    Li, Dandan
    Yan, Cilin
    Guo, Mingxing
    Zhao, Ying
    Zhang, Yang
    Cui, Xiangli
    [J]. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 2023, 89 (08) : 2423 - 2429
  • [39] Use of immortalized human hepatocytes to predict the magnitude of clinical drug-drug interactions caused by CYP3A4 induction
    Ripp, Sharon L.
    Mills, Jessica B.
    Fahmi, Odette A.
    Trevena, Kristen A.
    Liras, Jennifer L.
    Maurer, Tristan S.
    de Morais, Sonia M.
    [J]. DRUG METABOLISM AND DISPOSITION, 2006, 34 (10) : 1742 - 1748