Interleukin-1 beta enhances and tumor necrosis factor-alpha inhibits bone morphogenetic protein-2-induced alkaline phosphatase activity in MC3T3-E1 osteoblastic cells

被引：72

作者：

Nakase, T

Takaoka, K

Masuhara, K

Shimizu, K

Yoshikawa, H

Ochi, T

机构：

[1] SHINSHU UNIV,SCH MED,DEPT ORTHOPAED SURG,MATSUMOTO,NAGANO 390,JAPAN

[2] OSAKA POLICE HOSP,DEPT ORTHOPAED SURG,OSAKA,JAPAN

[3] OSAKA MED CTR CANC & CARDIOVASC DIS,DEPT ORTHOPAED SURG,OSAKA,JAPAN

来源：

BONE | 1997年 / 21卷 / 01期

关键词：

bone morphogenetic protein; alkaline phosphatase; interleukin-1; beta; tumor necrosis factor-alpha; osteoblast;

D O I：

10.1016/S8756-3282(97)00038-0

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The modulatory effects of interleukin (IL)-1 beta and tumor necrosis factor (TNF)-alpha on bone morphogenetic protein (BMP)-2- and -4-induced alkaline phosphatase (ALP) activity were examined in cultures of mouse MC3T3-E1 osteoblastic cells. Both BMP-2 and -4 significantly induced ALP in these cells. IL-1 beta alone had no effect on ALP activity, but it significantly enhanced BMP-2- and -4-induced ALP activity. TNF-alpha suppressed the induction of ALP by BMP-2 or -4. The results suggest that the action of BMP on osteogenic differentiation may be regulated by such immuno/inflammatory cytokines as IL-1 beta and TNF-alpha. (C) 1997 by Elsevier Science Inc. All rights reserved.

引用

页码：17 / 21

页数：5

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