Microwave assisted synthesis of phenanthridine derivatives via Suzuki coupling and condensation

被引：2

作者：

Dende, Satheesh Kumar ^{[1
,2
,3
]}

Korupolu, Raghu Babu ^{[2
]}

Doddipalla, Raju ^{[1
]}

Leleti, Krishnakanth Reddy ^{[1
]}

机构：

[1] GVK Biosci Private Ltd, Med Chem Div, 28A IDA Nacharam, Hyderabad 500076, India

[2] Andhra Univ, Coll Engn A, Dept Engn Chem, Visakhapatnam 530003, Andhra Pradesh, India

[3] Sai Life Sci Ltd, Med Chem Div, DS-7,ICICI Knowledge Pk, Hyderabad 500078, India

来源：

RESULTS IN CHEMISTRY | 2021年 / 3卷

关键词：

Phenanthridines; Tosylhydrazones; 2 '-aminophenylboronic acid pinacol esters; Suzuki coupling; Condensation reaction; One pot synthesis; N-TOSYLHYDRAZONES; EXPEDITIOUS SYNTHESIS; CASCADE; ALDEHYDES; ALKALOIDS; CONSTRUCTION; METALATION; QUINOLINES; SYNTHONS; ANALOGS;

D O I：

10.1016/j.rechem.2021.100149

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

One-pot synthesis of phenanthridine derivatives using appropriately substituted aromatic ortho-bromo N-tosylhydrazones and 2'-aminobenzeneboronic acid pinacol esters is described. In the presence of Pd(amphos)Cl-2 catalyst, tosylhydrazone precursors undergo a Suzuki cross-coupling reaction with 2'-aminobenzeneboronic acid pinacol ester derivatives followed by intramolecular condensation to form the corresponding phenanthridines derivatives in one step.

引用

页数：6

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