Heme oxygenase-1 expression in peripheral blood mononuclear cells correlates with disease activity in multiple sclerosis

被引：47

作者：

Fagone, Paolo ^{[1
]}

Patti, Francesco ^{[1
]}

Mangano, Katia ^{[1
]}

Mammana, Santa ^{[1
]}

Coco, Marinella ^{[1
]}

Touil-Boukoffa, Chafia ^{[2
]}

Chikovani, Tinatin ^{[3
]}

Di Marco, Roberto ^{[4
]}

Nicoletti, Ferdinando ^{[1
]}

机构：

[1] Univ Catania, Dept Biomed Sci, I-95124 Catania, Italy

[2] Univ Bab Ezzouar, Lab Cellular & Mol Biol, Algiers, Algeria

[3] Tbilisi 1st Hosp Univ Clin, High Technol Med Ctr, Tbilisi, Georgia

[4] Univ Molise, Dept Med & Hlth Sci, Campobasso, Italy

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2013年 / 261卷 / 1-2期

关键词：

Multiple sclerosis; HO-1; Autoimmunity; IFN-beta; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS; MIGRATION INHIBITORY FACTOR; REGULATORY T-CELLS; CARBON-MONOXIDE; SERUM-LEVELS; INTERFERON-BETA; MONOCYTES; GENE;

D O I：

10.1016/j.jneuroim.2013.04.013

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Multiple sclerosis (MS) is an immunoinflammatory disease that affects the central nervous system. Heme oxygenase-1 (HO-1) is one of the three isoforms of the heme oxygenase enzyme that catabolyzes the degradation of heme into biliverdin with the production of free iron and CO. We show in this study that HO-1 expression is reduced in PBMCs of MS patients and that during exacerbation of the disease there is a significant downregulation of this enzyme. We conclude that HO-1 may play a significant role in the maintenance of immune homeostasis which is disrupted in autoimmune disorders, such as MS. (C) 2013 Elsevier B.V. All rights reserved.

引用

页码：82 / 86

页数：5

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