Synthesis and reactions of enantiomerically pure chloromethyl oxiranes

被引：6
|
作者：
Abrate, F [1 ]
Bravo, P [1 ]
Frigerio, M [1 ]
Viani, F [1 ]
Zanda, M [1 ]
机构：
[1] CNR,CTR STUDIO SOSTANZE ORGAN NAT,I-20131 MILAN,ITALY
来源：
TETRAHEDRON-ASYMMETRY | 1996年 / 7卷 / 02期
关键词：
D O I：
10.1016/0957-4166(96)00042-0
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
The reactivities of 1-chloro-3-p-tolylsufinyl acetone (RS)-1 towards diazomethane and of the resulting diastereoisomeric 1-chloromethyl-1-sulfinylmethyl oxiranes 2 towards O-, N- and C-centred nucleophiles are investigated. The synthesis of differently functionalized homochiral chlorinated sulphur-free oxiranes (R)-15, (S)-16 and (R)-17 has been accomplished in good chemical yields.
引用
收藏
页码：581 / 594
页数：14
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