Association of Acute Cerebellar Ataxia and Human Papilloma Virus Vaccination: A Case Report

被引：8

作者：

Yonee, Chihiro ^{[1
]}

Toyoshima, Mitsuo ^{[1
]}

Maegaki, Yoshihiro ^{[2
]}

Kodama, Yuichi ^{[1
]}

Hayami, Hiroshi ^{[3
]}

Takahashi, Yukitoshi ^{[4
]}

Kusunoki, Susumu ^{[5
]}

Uchibori, Ayumi ^{[6
]}

Chiba, Atsuro ^{[6
]}

Kawano, Yoshifumi ^{[1
]}

机构：

[1] Kagoshima Univ, Grad Sch Med & Dent Sci, Dept Pediat, Kagoshima 8908520, Japan

[2] Tottori Univ, Fac Med, Inst Neurol Sci, Div Child Neurol, Yonago, Tottori 683, Japan

[3] Kagoshima Univ, Grad Sch Med & Dent Sci, Dept Urol, Kagoshima 8908520, Japan

[4] Shizuoka Inst Epilepsy & Neurol Disorders, Dept Pediat, Natl Epilepsy Ctr, Shizuoka, Japan

[5] Kinki Univ, Sch Med, Dept Neurol, Sayama, Osaka 589, Japan

[6] Kyorin Univ, Sch Med, Dept Neurol, Mitaka, Tokyo 181, Japan

来源：

NEUROPEDIATRICS | 2013年 / 44卷 / 05期

关键词：

acute cerebellar ataxia; human papilloma virus vaccination; immunoadsorption plasmapheresis therapy;

D O I：

10.1055/s-0033-1333873

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Introduction We report the case of a patient who developed symptoms of acute cerebellar ataxia (ACA) after administration of the human papilloma virus (HPV)-16/18 vaccine. Patient and Method This patient developed symptoms of ACA, including nausea, vertigo, severe limb and truncal ataxia, and bilateral spontaneous continuous horizontal nystagmus with irregular rhythm, 12 days after administration of the HPV-16/18 AS04-adjuvanted cervical cancer vaccine. After this, the patient received methylprednisolone pulse and intravenous immunoglobulin (IVIG) therapies as well as immunoadsorption plasmapheresis. Results Severe ACA symptoms did not improve after methylprednisolone pulse and IVIG therapies, but the patient recovered completely after immunoadsorption plasmapheresis. Conclusion This temporal association strongly suggests that ACA was induced by the vaccination.

引用

页码：265 / 267

页数：3

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