Clustering of Tuberculosis Cases Based on Variable-Number Tandem-Repeat Typing in Relation to the Population Structure of Mycobacterium tuberculosis in the Netherlands

被引:21
|
作者
Sloot, Rosa [1 ]
Borgdorff, Martien W. [2 ]
de Beer, Jessica L. [3 ]
van Ingen, Jakko [4 ]
Supply, Philip [5 ,6 ,7 ,8 ,9 ]
van Soolingen, Dick [3 ,4 ,10 ]
机构
[1] Univ Amsterdam, Acad Med Ctr, Dept Clin Epidemiol Biostat & Bioinformat, NL-1105 AZ Amsterdam, Netherlands
[2] Publ Hlth Serv, Dept Infect Dis, Amsterdam, Netherlands
[3] Natl Inst Publ Hlth & Environm, Natl TB Reference Lab, NL-3720 BA Bilthoven, Netherlands
[4] Radboud Univ Nijmegen, Med Ctr, Dept Med Microbiol, NL-6525 ED Nijmegen, Netherlands
[5] Ctr Infect & Immun Lille, INSERM, U1019, Lille, France
[6] Ctr Infect & Immun Lille, CNRS, Unite Mixte Rech 8204, Lille, France
[7] Univ Lille Nord France, Ctr Infect & Immun Lille, Lille, France
[8] Inst Pasteur, Ctr Infect & Immun Lille, F-59019 Lille, France
[9] GenoScreen, Lille, France
[10] Radboud Univ Nijmegen, Med Ctr, Dept Pulm Dis, NL-6525 ED Nijmegen, Netherlands
关键词
MOLECULAR EPIDEMIOLOGY; SAN-FRANCISCO; IMMIGRATION; TRANSMISSION; NATIONWIDE; INFECTION; PATTERNS; COUNTRY;
D O I
10.1128/JCM.00489-13
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
The population structure of 3,776 Mycobacterium tuberculosis isolates was determined using variable-number tandem-repeat (VNTR) typing. The degree of clonality was so high that a more relaxed definition of clustering cannot be applied. Among recent immigrants with non-Euro-American isolates, transmission is overestimated if based on identical VNTR patterns.
引用
收藏
页码:2427 / 2431
页数:5
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