Enantioselective synthesis of indole derivatives by Rh/Pd relay catalysis and their anti-inflammatory evaluation

被引：28

作者：

Li, Sifeng ^{[1
,2
]}

Wang, Zihao ^{[1
,2
]}

Xiao, Haitao ^{[3
]}

Bian, Zhaoxiang ^{[2
]}

Wang, Jun ^{[1
]}

机构：

[1] Southern Univ Sci & Technol, Dept Chem, Shenzhen 518055, Peoples R China

[2] Hong Kong Baptist Univ, Sch Chinese Med, Hong Kong, Peoples R China

[3] Shenzhen Univ, Hlth Sci Ctr, Sch Pharmaceut Sci, Shenzhen 518066, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2020年 / 56卷 / 55期

关键词：

RING-OPENING REACTION; ONE-POT SYNTHESIS; BIOLOGICAL EVALUATION; ASYMMETRIC-SYNTHESIS; IN-VITRO; OXABENZONORBORNADIENES; PALLADIUM; METAL; DESIGN; CYCLIZATION;

D O I：

10.1039/d0cc03158e

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An efficient Rh/Pd relay catalyzed intermolecular and cascade intramolecular hydroamination for the synthesis of exclusivetrans1-indolyl dihydronaphthalenols (up to 88% yield, 99% ee) is described under mild conditions. Moreover, thein silicoandin vitroscreening showed that the novel 1-indolyl dihydronaphthalenol products are potent lead compounds for treating inflammation disease.

引用

页码：7573 / 7576

页数：4

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