The BTBR T+tf/J mouse model for autism spectrum disorders-in search of biomarkers

被引：100
|
作者：
Meyza, Ksenia Z. [1 ]
Defensor, Erwin B. [1 ,2 ]
Jensen, Ashley L. [2 ]
Corley, Michael J. [2 ]
Pearson, Brandon L. [1 ,2 ]
Pobbe, Roger L. H. [1 ]
Bolivar, Valerie J. [3 ]
Blanchard, D. Caroline [1 ]
Blanchard, Robert J. [1 ,2 ]
机构：
[1] Univ Hawaii, Pacific Biosci Res Ctr, Honolulu, HI 96822 USA
[2] Univ Hawaii, Dept Psychol, Honolulu, HI 96822 USA
[3] New York State Dept Hlth, Wadsworth Ctr, Albany, NY 12208 USA
来源：
BEHAVIOURAL BRAIN RESEARCH | 2013年 / 251卷
关键词：
BTBR T(+)tf/J mouse; Autism spectrum disorder; Social interaction; Agenesis of corpus callosum; Biomarkers; T PLUS TF/J; SOCIAL APPROACH BEHAVIORS; CORPUS-CALLOSUM SIZE; ULTRASONIC VOCALIZATIONS; KYNURENIC ACID; SCENT-MARKING; EXTRACELLULAR-MATRIX; UNUSUAL REPERTOIRE; ANIMAL-MODELS; C57BL/6J MICE;
D O I：
10.1016/j.bbr.2012.07.021
中图分类号：
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号：
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要：
Autism spectrum disorders (ASD) form a common group of neurodevelopmental disorders appearing to be under polygenic control, but also strongly influenced by multiple environmental factors. The brain mechanisms responsible for ASD are not understood and animal models paralleling related emotional and cognitive impairments may prove helpful in unraveling them. BTBR T(+)tf/J (BTBR) mice display behaviors consistent with the three diagnostic categories for ASD. They show impaired social interaction and communication as well as increased repetitive behaviors. This review covers much of the data available to date on BTBR behavior, neuroanatomy and physiology in search for candidate biomarkers, which could both serve as diagnostic tools and help to design effective treatments for the behavioral symptoms of ASD. (C) 2012 Elsevier B.V. All rights reserved.
引用
收藏
页码：25 / 34
页数：10
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