Reduced sulfate plasma concentrations in the BTBR T plus tf/J mouse model of autism

被引：7
|
作者：
Corley, Michael J. [1 ,2 ]
Meyza, Ksenia Z. [2 ]
Blanchard, D. Caroline [2 ]
Blanchard, Robert J. [1 ,2 ]
机构：
[1] Univ Hawaii, Dept Psychol, Honolulu, HI 96822 USA
[2] Univ Hawaii, Pacific Biosci Res Ctr, Honolulu, HI 96822 USA
来源：
PHYSIOLOGY & BEHAVIOR | 2012年 / 107卷 / 05期
关键词：
Autism spectrum disorders; Animal model; BTBR; Sulfate; CORPUS-CALLOSUM; HEPARAN-SULFATE; INBRED STRAINS; INORGANIC SULFATE; MICE; CHILDREN; BEHAVIORS; RELEVANT; VOCALIZATIONS; TRANSPORTERS;
D O I：
10.1016/j.physbeh.2012.04.010
中图分类号：
B84 [心理学];
学科分类号：
04 ; 0402 ;
摘要：
Clinical studies have shown that children diagnosed with autism show abnormal sulfate chemistry, which is critical for cellular and metabolic processes. To determine if the inbred BTBR T+tf/J mouse shows autism-relevant aberrations in sulfate chemistry, the present study examined plasma sulfate concentrations in BTBR T+tf/J, inbred C57BL/6J, and outbred CD-1 mice. Results showed that the BTBR T+tf/J mouse exhibits significantly lower plasma sulfate concentrations in comparison to both C57BL/6J and CD-1 mice. These results suggest that the BTBR mouse shows autism-relevant abnormalities in sulfate chemistry and may serve additional utility in examining the role of sulfate and sulfate-dependent systems in relation to autism-relevant behavioral aberrations. (C) 2012 Elsevier Inc. All rights reserved.
引用
收藏
页码：663 / 665
页数：3
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