A novel heterologous prime boost vaccine system drives tumor specific and potent CD8 T cell responses for cancer immunotherapy

被引:0
|
作者
Blair, Wade [1 ]
Grotenbreg, Gijsbert [1 ]
Scallan, Ciaran [1 ]
Rappaport, Amy [1 ]
Greer, Renee [1 ]
Gitlin, Leonid [1 ]
Lam, Kieu [2 ]
Heyes, James [2 ]
Van Abbema, Anne [1 ]
Hanson, Hadley [1 ]
Schreiner, Petra [2 ]
Jooss, Karin [1 ]
机构
[1] Gritstone Oncol, Emeryville, CA USA
[2] Arbutus Biopharma, Burnby, BC, Canada
关键词
D O I
10.1158/1538-7445.AM2018-724
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
724
引用
收藏
页数:2
相关论文
共 50 条
  • [31] CD4 and CD8 T Cell Responses to the M. tuberculosis Ag85B-TB10.4 Promoted by Adjuvanted Subunit, Adenovector or Heterologous Prime Boost Vaccination
    Elvang, Tara
    Christensen, Jan P.
    Billeskov, Rolf
    Hoang, Truc Thi Kim Thanh
    Holst, Peter
    Thomsen, Allan Randrup
    Andersen, Peter
    Dietrich, Jes
    PLOS ONE, 2009, 4 (04):
  • [32] How tumor-specific CD8 T cell activation in draining lymph nodes supports the anti-tumor CD8 T cell response
    Prokhnevska, Nataliya
    Valanparambil, Rajesh
    Jansen, Caroline
    Master, Viraj
    Sanda, Martin
    Kissick, Haydn
    JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2019, 7
  • [33] Obesity and CD8 T cell metabolism: Implications for anti-tumor immunity and cancer immunotherapy outcomes
    Turbitt, William J.
    Rosean, Claire Buchta
    Weber, K. Scott
    Norian, Lyse A.
    IMMUNOLOGICAL REVIEWS, 2020, 295 (01) : 203 - 219
  • [34] CD8 T cell responses to live, viral Yellow fever vaccine in humans
    Akondy, Rama
    Miller, Joseph
    Monson, Nathan
    Wu, Hong
    Quyyumi, Farah
    Mulligan, Mark
    Teuwen, Dirk
    Altman, John
    Ahmed, Rafi
    FASEB JOURNAL, 2008, 22
  • [35] Selective alterations in viral epitope-specific CD8 T cell responses as a consequence of infections with heterologous viruses.
    Selin, LK
    Lin, MY
    Santolucito, PA
    Pinto, AK
    Welsh, RM
    FASEB JOURNAL, 2000, 14 (06): : A978 - A978
  • [36] Intracellular immunotherapy of disseminated pancreatic cancer activates potent IFNγ and CD8+T cell dependent anti-tumor responses
    Sanders, Kiah L.
    Fox, Barbara A.
    Bzik, David J.
    CANCER RESEARCH, 2015, 75
  • [37] Tailored Tumor Immunogenicity Reveals Regulation of CD4 and CD8 T Cell Responses against Cancer
    Knocke, Sarah
    Fleischmann-Mundt, Bettina
    Saborowski, Michael
    Manns, Michael P.
    Kuehnel, Florian
    Wirth, Thomas C.
    Woller, Norman
    CELL REPORTS, 2016, 17 (09): : 2234 - 2246
  • [38] Airway delivery of both a BCG prime and adenoviral boost drives CD4 and CD8 T cells into the lung tissue parenchyma
    Daryan A. Kaveh
    M. Carmen Garcia-Pelayo
    Naomi C. Bull
    Pedro J. Sanchez-Cordon
    John Spiropoulos
    Philip J. Hogarth
    Scientific Reports, 10
  • [39] Airway delivery of both a BCG prime and adenoviral boost drives CD4 and CD8 T cells into the lung tissue parenchyma
    Kaveh, Daryan A.
    Garcia-Pelayo, M. Carmen
    Bull, Naomi C.
    Sanchez-Cordon, Pedro J.
    Spiropoulos, John
    Hogarth, Philip J.
    SCIENTIFIC REPORTS, 2020, 10 (01)
  • [40] Phenotypic and Functional Profile of HIV-Inhibitory CD8 T Cells Elicited by Natural Infection and Heterologous Prime/Boost Vaccination
    Freel, Stephanie A.
    Lamoreaux, Laurie
    Chattopadhyay, Pratip K.
    Saunders, Kevin
    Zarkowsky, David
    Overman, R. Glenn
    Ochsenbauer, Christina
    Edmonds, Tara G.
    Kappes, John C.
    Cunningham, Coleen K.
    Denny, Thomas N.
    Weinhold, Kent J.
    Ferrari, Guido
    Haynes, Barton F.
    Koup, Richard A.
    Graham, Barney S.
    Roederer, Mario
    Tomaras, Georgia D.
    JOURNAL OF VIROLOGY, 2010, 84 (10) : 4998 - 5006