A data-based photonuclear simulation algorithm for determining specific activity of medical radioisotopes

For simulating more accurately neutron or proton production from photonuclear reactions, a data-based photonuclear reaction simulation algorithm has been developed. Reliable photonuclear cross sections from evaluated or experimental database are chosen as input data. For checking the validity of the use of the data-based photonuclear algorithm, benchmarking simulations are presented in detail. We calculate photonuclear cross sections or reaction yield for Be-9, Ti-48, Cs-133, and Au-197 and compare them with experimental data in the region of incident photon energy below similar to 30 MeV. While Geant4 can hardly reproduce photonuclear experimental data, results obtained from the data-based photonuclear algorithm are found in good agreement with experimental measurements. Potential application in estimation of specific activity of radioisotopes is further discussed. We conclude that the developed data-based photonuclear algorithm is suitable for an accurate prediction of photoninduced neutron or proton productions.