Neurotrophic Keratitis

被引：84
|
作者：
Semeraro, F. [1 ]
Forbice, E. [1 ]
Romano, V. [2 ]
Angi, M. [2 ]
Romano, M. R. [2 ,3 ]
Filippelli, M. E. [2 ]
Di Iorio, R. [2 ]
Costagliola, C. [2 ]
机构：
[1] Univ Brescia, Dept Ophthalmol, Eye Clin, IT-25100 Brescia, Italy
[2] Univ Molise, Dept Hlth Sci, Eye Clin, Campobasso, Italy
[3] Ist Clin Humanitas, Eye Unit, Rozzano, Italy
来源：
OPHTHALMOLOGICA | 2014年 / 231卷 / 04期
关键词：
Neurotrophic keratitis; Corneal sensitivity; Trigeminal nerve; Corneal vascularization; Stromal ulcers; NERVE GROWTH-FACTOR; PERSISTENT EPITHELIAL DEFECTS; AMNIOTIC MEMBRANE TRANSPLANTATION; AUTOLOGOUS SERUM APPLICATION; SCLERAL CONTACT-LENSES; IN-VITRO TOXICITY; SEVERE DRY EYE; SUBSTANCE-P; PENETRATING KERATOPLASTY; CORNEAL SENSITIVITY;
D O I：
10.1159/000354380
中图分类号：
R77 [眼科学];
学科分类号：
100212 ;
摘要：
Neurotrophic keratitis (NK) is a rare degenerative corneal disease that occurs as a result of partial or total impairment of trigeminal innervations, leading to a reduction (hypoesthesia) in or loss (anaesthesia) of corneal sensitivity. The impairment of sensory innervation causes a reduction in the lacrimation reflex and the vitality, metabolism and mitosis of epithelial cells, with subsequent deficiency in epithelial repair, stromal and intracellular oedema, loss of microvilli, and abnormal development of the basal lamina. Several recent studies have proposed different therapies based on different aetiopathogenetic theories. The aim of the therapy is to treat aetiopathogenesis and, at the same time, promote corneal healing. In this paper, we report the aetiology, diagnosis, management, and medical and surgical treatment of NK, also indicating future treatments based on the most recent studies. (c) 2013 S. Karger AG, Basel
引用
收藏
页码：191 / 197
页数：7
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