Asymmetric total synthesis of Lycopodium alkaloid (+)-lycopladine A

被引：11

作者：

Xu, Tao ^{[1
,2
]}

Luo, Xiu-Li ^{[1
,2
]}

Yang, Yu-Rong ^{[1
]}

机构：

[1] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China

[2] Univ Chinese Acad Sci, Beijing 100049, Peoples R China

来源：

TETRAHEDRON LETTERS | 2013年 / 54卷 / 22期

关键词：

Total synthesis; Lycopladine A; Lycopodium alkaloids; HELQUIST ANNULATION; (-)-LYCOJAPODINE; (-)-8-DEOXYSERRATININE; LYCOPLADINE; STRATEGY;

D O I：

10.1016/j.tetlet.2013.03.097

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Asymmetric total synthesis of (+)-lycopladine A (1) has been achieved. Key elements of the synthesis include an efficient Helquist annulation to assemble the cis-fused 6/5 bicycle, Stille coupling reaction to elongate the allylic side chain, and Krohnke pyridine synthesis to set the pyridine core at the final stage. (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：2858 / 2860

页数：3

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