Inclusion complexes of chlorzoxazone with β- and hydroxypropyl-β-cyclodextrin: Characterization, dissolution, and cytotoxicity

被引：89
|
作者：
Tang, Peixiao [1 ]
Li, Shanshan [1 ]
Wang, Lili [1 ]
Yang, Hongqin [1 ]
Yan, Jin [1 ]
Li, Hui [1 ]
机构：
[1] Sichuan Univ, Coll Chem Engn, Chengdu 610065, Peoples R China
来源：
CARBOHYDRATE POLYMERS | 2015年 / 131卷
关键词：
Chlorzoxazone; beta-Cyclodextrin; Hydroxypropyl-beta-cyclodextrin; Inclusion complex; Solubilization; In vitro cytotoxicity; DERIVATIVES; SOLUBILITY; UV;
D O I：
10.1016/j.carbpol.2015.05.055
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
This study aimed to improve the water solubility and reduce the toxicity of chlorzoxazone via complexation with beta-cyclodextrin (beta-CD) and hydroxypropyl-beta-cyclodextrin (HP-beta-CD). Inclusion complexes between chlorzoxazone and the two cyclodextrins (CDs) were prepared by freeze-drying method. Formation of the complexes was confirmed by FT-IR, PXRD, H-1 NMR, DSC, and SEM. The water solubility and dissolution rates of chlorzoxazone were significantly increased by complexation with the two CDs. Preliminary in vitro cytotoxicity tests showed that the complexes are less toxic to normal liver cells than free chlorzoxazone. In general, the HP-beta-CD complex exhibited better dissolution properties than the beta-CD complex in various dissolution media. Therefore, the HP-beta-CD complex can be used to design novel formulations of chlorzoxazone. (C) 2015 Elsevier Ltd. All rights reserved.
引用
收藏
页码：297 / 305
页数：9
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