Novel biomarkers for the prediction of acute kidney injury in patients undergoing liver transplantation

被引：19

作者：

Dedeoglu, Burc ^{[1
]}

de Geus, Hilde R. H. ^{[2
]}

Fortrie, Gijs ^{[1
]}

Betjes, Michiel G. H. ^{[1
,3
]}

机构：

[1] Erasmus Univ, Med Ctr, Dept Nephrol, Rotterdam, Netherlands

[2] Erasmus Univ, Med Ctr, Dept Intens Care, Rotterdam, Netherlands

[3] Erasmus MC, Dept Nephrol & Transplantat, NL-3000 CA Rotterdam, Netherlands

来源：

BIOMARKERS IN MEDICINE | 2013年 / 7卷 / 06期

关键词：

cystatin C; glutathione S-transferase; kidney injury molecule-1; neutrophil gelatinase-associated lipocalin; serum creatinine; GELATINASE-ASSOCIATED LIPOCALIN; INTENSIVE-CARE-UNIT; ACUTE-RENAL-FAILURE; SERUM CYSTATIN-C; CARDIAC-SURGERY; MOLECULE-1; KIM-1; URINARY BIOMARKERS; CREATININE; DEFINITION; EXPRESSION;

D O I：

10.2217/bmm.13.91

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Aim: Because of the delayed rise of serum creatinine concentrations, novel biomarkers such as NGAL, GST and KIM-1 are proposed to detect acute kidney injury (AKI). In this study we evaluated these biomarkers. Materials & methods: Twenty-six consecutive adult liver transplantations were evaluated. Markers were measured at four different time points during an intensive care unit admission. Results: Plasma NGAL detected AKI with an optimal area under the curve at 8 h after admission (0.86; p = 0.004) and at 4 h after admission for urinary NGAL (0.80; p = 0.012). The other markers failed to detect AKI. Conclusion: NGAL is a promising biomarker for detecting AKI in patients after liver transplantation.

引用

页码：947 / 957

页数：11

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