Biomechanical properties of tissue-engineered cartilage from human and rabbit chondrocytes

被引：5
|
作者：
Park, SS
Chi, DH
Lee, AS
Taylor, SR
Iezzoni, JC
机构：
[1] Univ Virginia, Med Ctr, Dept Otolaryngol Head & Neck Surg, Charlottesville, VA 22908 USA
[2] Univ Virginia, Dept Mat Sci & Engn, Charlottesville, VA 22908 USA
[3] Univ Virginia, Dept Pathol, Charlottesville, VA 22908 USA
来源：
OTOLARYNGOLOGY-HEAD AND NECK SURGERY | 2002年 / 126卷 / 01期
关键词：
D O I：
10.1067/mhn.2002.121021
中图分类号：
R76 [耳鼻咽喉科学];
学科分类号：
100213 ;
摘要：
OBJECTIVE: To describe tissue-engineered cartilage from rabbit and human chondrocytes. STUDY DESIGN AND SETTING: Chondrocytes from rabbit and human ears were seeded onto a template and implanted for 8 or 16 weeks of in vivo incubation. RESULTS: For the 8-week and 16-week groups, the UTS for cartilage was 3.8 MPa and 3.7 MPa, stiffness was 62.4 MPa and 51.8 MPa, and resilience was 181.8 J/m(3) and 109.1 J/m(3), respectively. Experimental cartilage was significantly different from controls. From 5 human specimens, the UTS was 5.4 MPa, stiffness was 6.6 MPa, and resilience was 2.0 J/m(3). The control had UTS of 8.8 MPa, stiffness of 12.2 MPa, and resilience of 2.9 J/m(3), Histology showed mature cartilage but with a fibrovascular infiltrate and increased cellularity. CONCLUSIONS: Mechanical properties of tissue-engineered cartilage can be quantified and are less than that of controls.
引用
收藏
页码：52 / 57
页数：6
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