Plakoglobin localization to the cell border restores desmosome function in cells lacking 14-3-3γ

被引：6
|
作者：
Vishal, Sonali S. [1 ,2 ]
Tilwani, Sarika [1 ,2 ]
Dalal, Sorab N. [1 ,2 ]
机构：
[1] Tata Mem Hosp, ACTREC, KS215, Kharghar Node 410210, Navi Mumbai, India
[2] Homi Bhabha Natl Inst, Training Sch Complex, Bombay 400085, Maharashtra, India
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2018年 / 495卷 / 02期
关键词：
Desmosome; Plakoglobin; Cell-cell adhesion; 14-3-3; gamma; STRIATE PALMOPLANTAR KERATODERMA; HUMAN AUTOANTIBODIES; WOOLLY HAIR; IN-VIVO; BINDING; DESMOPLAKIN; PEMPHIGUS; ADHESION; CADHERIN; DISEASE;
D O I：
10.1016/j.bbrc.2017.12.080
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Desmosomes are cell-cell adhesion junctions that anchor intermediate filaments. Loss of 14-3-3 gamma in HCT116 cells led to defects in desmosome assembly due to a decrease in the transport of Plakoglobin (PG) to the cell border thus disrupting desmosome formation. Desmosome formation in cells lacking 14-3-3 gamma was restored by artificially localizing PG to the cell border by fusing it to EGFP-f (PG-EGFP-f). These results suggest that a major role of 14-3-3 gamma in desmosome assembly is to transport PG to the cell border leading to the initiation of desmosome formation. (C) 2017 Elsevier Inc. All rights reserved.
引用
收藏
页码：1998 / 2003
页数：6
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