Plakoglobin localization to the cell border restores desmosome function in cells lacking 14-3-3γ

被引：6

作者：

Vishal, Sonali S. ^{[1
,2
]}

Tilwani, Sarika ^{[1
,2
]}

Dalal, Sorab N. ^{[1
,2
]}

机构：

[1] Tata Mem Hosp, ACTREC, KS215, Kharghar Node 410210, Navi Mumbai, India

[2] Homi Bhabha Natl Inst, Training Sch Complex, Bombay 400085, Maharashtra, India

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2018年 / 495卷 / 02期

关键词：

Desmosome; Plakoglobin; Cell-cell adhesion; 14-3-3; gamma; STRIATE PALMOPLANTAR KERATODERMA; HUMAN AUTOANTIBODIES; WOOLLY HAIR; IN-VIVO; BINDING; DESMOPLAKIN; PEMPHIGUS; ADHESION; CADHERIN; DISEASE;

D O I：

10.1016/j.bbrc.2017.12.080

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Desmosomes are cell-cell adhesion junctions that anchor intermediate filaments. Loss of 14-3-3 gamma in HCT116 cells led to defects in desmosome assembly due to a decrease in the transport of Plakoglobin (PG) to the cell border thus disrupting desmosome formation. Desmosome formation in cells lacking 14-3-3 gamma was restored by artificially localizing PG to the cell border by fusing it to EGFP-f (PG-EGFP-f). These results suggest that a major role of 14-3-3 gamma in desmosome assembly is to transport PG to the cell border leading to the initiation of desmosome formation. (C) 2017 Elsevier Inc. All rights reserved.

引用

页码：1998 / 2003

页数：6

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