DISC1 Partners with GSK3β in Neurogenesis

被引：49
|
作者：
Ming, Guo-li [1 ,2 ,3 ]
Song, Hongjun [1 ,2 ,3 ]
机构：
[1] Johns Hopkins Univ, Inst Cell Engn, Sch Med, Baltimore, MD 21205 USA
[2] Johns Hopkins Univ, Dept Neurol, Sch Med, Baltimore, MD 21205 USA
[3] Johns Hopkins Univ, Solomon H Snyder Dept Neurosci, Sch Med, Baltimore, MD 21205 USA
来源：
CELL | 2009年 / 136卷 / 06期
关键词：
SCHIZOPHRENIA; NEURONS;
D O I：
10.1016/j.cell.2009.03.005
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The protein DISC1, encoded by a gene implicated in schizophrenia susceptibility, regulates the development of postmitotic neurons. Mao et al. (2009) now report that DISC1 also regulates the proliferation of embryonic and adult neural progenitor cells through the GSK3 beta/beta-catenin pathway, providing new insights into how susceptibility genes may contribute to the etiology of psychiatric disorders.
引用
收藏
页码：990 / 992
页数：3
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