Catalytic Asymmetric Construction of Chiral Hydropyridazines via Conjugate Addition of N-Monosubstituted Hydrazones to Enones

被引：46

作者：

Wu, Wenbin ^{[1
]}

Yuan, Xiaoqian ^{[1
]}

Hu, Juan ^{[1
]}

Wu, Xinxin ^{[1
]}

Wei, Yuan ^{[1
]}

Liu, Zunwu ^{[1
]}

Lu, Junzhu ^{[1
]}

Ye, Jinxing ^{[1
]}

机构：

[1] E China Univ Sci & Technol, Sch Pharm, Minist Educ, Engn Res Ctr Pharmaceut Proc Chem, Shanghai 200237, Peoples R China

来源：

ORGANIC LETTERS | 2013年 / 15卷 / 17期

基金：

中国国家自然科学基金;

关键词：

FORMALDEHYDE N; N-DIALKYLHYDRAZONES; ENANTIOSELECTIVE SYNTHESIS; ALPHA; BETA-UNSATURATED KETONES; MICHAEL REACTIONS; SAMP-HYDRAZONE; ACID; UMPOLUNG; ANION; REACTIVITY; PYRAZOLINE;

D O I：

10.1021/ol4020865

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The first example of a highly enantioselective and scalable formal diaza-ene reaction between N-monosubstituted hydrazones and enones catalyzed by a simple chiral primary-second diamine salt has been developed. The catalytic process provides a highly practical and stereoselective synthetic method for chiral hydropyridazines.

引用

页码：4524 / 4527

页数：4

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