Thumb II Site Inhibitor Allosterically Suppresses the Dynamics of HCV RNA-Dependent RNA Polymerase

被引:0
|
作者
Deredge, Daniel J. [1 ]
Johnson, Kenneth [2 ]
Wintrode, Patrick [1 ]
机构
[1] Univ Maryland, Sch Pharm, Pharmaceut Sci, Baltimore, MD 21201 USA
[2] Univ Texas Austin, Inst Cellular & Mol Biol, Austin, TX 78712 USA
关键词
D O I
10.1016/j.bpj.2014.11.2900
中图分类号
Q6 [生物物理学];
学科分类号
071011 ;
摘要
2677-Pos
引用
收藏
页码:529A / 529A
页数:1
相关论文
共 50 条
  • [41] An RNA-dependent RNA polymerase formed by TERT and the RMRP RNA
    Maida, Yoshiko
    Yasukawa, Mami
    Furuuchi, Miho
    Lassmann, Timo
    Possemato, Richard
    Okamoto, Naoko
    Kasim, Vivi
    Hayashizaki, Yoshihide
    Hahn, William C.
    Masutomi, Kenkichi
    NATURE, 2009, 461 (7261) : 230 - U104
  • [42] Resistance to HCV nucleoside analogue inhibitors of hepatitis C virus RNA-dependent RNA polymerase
    Najera, Isabel
    CURRENT OPINION IN VIROLOGY, 2013, 3 (05) : 508 - 513
  • [43] The Crystal Structure of a Cardiovirus RNA-Dependent RNA Polymerase Reveals an Unusual Conformation of the Polymerase Active Site
    Vives-Adrian, Laia
    Lujan, Celia
    Oliva, Baldo
    van der Linden, Lonneke
    Selisko, Barbara
    Coutard, Bruno
    Canard, Bruno
    van Kuppeveld, Frank J. M.
    Ferrer-Orta, Cristina
    Verdaguer, Nuria
    JOURNAL OF VIROLOGY, 2014, 88 (10) : 5595 - 5607
  • [44] Hepatitis C RNA-dependent RNA polymerase (II): De novo initiation of RNA replication
    Zhong, WD
    Uss, A
    Ferrari, E
    Lau, J
    Hong, Z
    HEPATOLOGY, 1999, 30 (04) : 449A - 449A
  • [45] Conformational Flexibility of the Dengue Virus RNA-Dependent RNA Polymerase Revealed by a Complex with an Inhibitor
    Noble, Christian G.
    Lim, Siew Pheng
    Chen, Yen-Liang
    Liew, Chong Wai
    Yap, Lijian
    Lescar, Julien
    Shi, Pei-Yong
    JOURNAL OF VIROLOGY, 2013, 87 (09) : 5291 - 5295
  • [46] The monoethyl ester of meconic acid is an active site inhibitor of HCVNS5B RNA-dependent RNA polymerase
    Pace, P
    Nizi, E
    Pacini, B
    Pesci, S
    Matassa, V
    De Francesco, R
    Altamura, S
    Summa, V
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2004, 14 (12) : 3257 - 3261
  • [47] Kaempferol as a novel inhibitor of SARS-CoV-2 RNA-dependent RNA polymerase
    Medoro, Alessandro
    Benedetti, Francesca
    Intrieri, Mariano
    Jafar, Tassadaq Hussain
    Ali, Sawan
    Trung, Truong Tan
    Passarella, Daniela
    Ismail, Saba
    Zella, Davide
    Scapagnini, Giovanni
    Davinelli, Sergio
    JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS, 2024,
  • [48] Resistance profile of a hepatitis C virus RNA-dependent RNA polymerase benzothiadiazine inhibitor
    Nguyen, TT
    Gates, AT
    Gutshall, LL
    Johnston, VK
    Gu, BH
    Duffy, KJ
    Sarisky, RT
    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2003, 47 (11) : 3525 - 3530
  • [49] Site size of cooperative single-stranded RNA binding by poliovirus RNA-dependent RNA polymerase
    Beckman, MTL
    Kirkegaard, K
    JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (12) : 6724 - 6730
  • [50] Activation mechanism of a noncanonical RNA-dependent RNA polymerase
    Garriga, Damia
    Navarro, Aitor
    Querol-Audi, Jordi
    Abaitua, Fernando
    Rodriguez, Jose F.
    Verdaguer, Nuria
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (51) : 20540 - 20545