Development of a lysophosphatidic acid receptor 1 (LPA1) radioligand for lung imaging with PET

被引:0
|
作者
Gallezot, Jean-Dominique [1 ]
Nabulsi, Nabeel [1 ]
Holden, Daniel [1 ]
Donnelly, David [2 ]
Cao, Kai [2 ]
Bonacorsi, Samuel [2 ]
Hayes, Wendy [3 ]
Huang, Yiyun [1 ]
Du, Shuyan [3 ]
Carson, Richard [1 ]
机构
[1] Yale Univ, Diagnost Radiol, New Haven, CT USA
[2] Bristol Myers Squibb Co, Radiochem, Princeton, NJ USA
[3] Bristol Myers Squibb Co, Imaging, Princeton, NJ USA
关键词
D O I
暂无
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
96
引用
收藏
页数:1
相关论文
共 50 条
  • [41] Loss of lysophosphatidic acid receptor LPA1 alters oligodendrocyte differentiation and myelination in the mouse cerebral cortex
    Garcia-Diaz, Beatriz
    Riquelme, Raquel
    Varela-Nieto, Isabel
    Jesus Jimenez, Antonio
    de Diego, Isabel
    lsabel Gomez-Conde, Ana
    Matas-Rico, Elisa
    Angel Aguirre, Jose
    Chun, Jerold
    Pedraza, Carmen
    Javier Santin, Luis
    Fernandez, Oscar
    Rodriguez de Fonseca, Fernando
    Estivill-Torrus, Guillermo
    BRAIN STRUCTURE & FUNCTION, 2015, 220 (06): : 3701 - 3720
  • [42] Defective myelination in mice lacking the lysophosphatidic acid receptor LPA1:: newcomer models for demyelinating diseases
    Garcia-Diaz, B.
    Matas-Rico, E.
    Riquelme, R.
    Varela-Nieto, I.
    Jimenez, A. J.
    Chun, J.
    Leyva, L.
    Fernandez, O.
    Rodriguez de Fonseca, F.
    Estivill-Torrus, G.
    MULTIPLE SCLEROSIS, 2007, 13 : S258 - S258
  • [43] The Role of Lysophosphatidic Acid Receptor (LPA1) in the Oxygen-Induced Retinal Ganglion Cell Degeneration
    Yang, Chun
    Lafleur, Josiane
    Mwaikambo, Bupe R.
    Zhu, Tang
    Gagnon, Carmen
    Chemtob, Sylvain
    Di Polo, Adriana
    Hardy, Pierre
    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2009, 50 (03) : 1290 - 1298
  • [44] Lysophosphatidic Acid Receptor Type 1 (LPA1) Plays a Functional Role in Osteoclast Differentiation and Bone Resorption Activity
    David, Marion
    Machuca-Gayet, Irma
    Kikuta, Junichi
    Ottewell, Penelope
    Mima, Fuka
    Leblanc, Raphael
    Bonnelye, Edith
    Ribeiro, Johnny
    Holen, Ingunn
    Lopez Vales, Ruben
    Jurdic, Pierre
    Chun, Jerold
    Clezardin, Philippe
    Ishii, Masaru
    Peyruchaud, Olivier
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2014, 289 (10) : 6551 - 6564
  • [45] Different mechanisms regulate lysophosphatidic acid (LPA)-dependent versus phorbol ester-dependent internalization of the LPA1 receptor
    Urs, Nikhil M.
    Kowalczyk, Andrew P.
    Radhakrishna, Harish
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2008, 283 (09) : 5249 - 5257
  • [46] Integrin signalling regulates the nuclear localization and function of the lysophosphatidic acid receptor-1 (LPA1) in mammalian cells
    Waters, Catherine M.
    Saatian, Bahman
    Moughal, Noreen A.
    Zhao, Yutong
    Tigyi, Gabor
    Natarajan, Viswanathan
    Pyne, Susan
    Pyne, Nigel J.
    BIOCHEMICAL JOURNAL, 2006, 398 : 55 - 62
  • [47] Analysis of Antidepressant Agonist Activity at LPA1, LPA2 and LPA3 lysophosphatidic acid receptors
    Olianas, Maria
    Dedoni, Simona
    Marras, Luisa
    Ingianni, Angela
    Onali, Pierluigi
    FASEB JOURNAL, 2020, 34
  • [48] Isolation of Single Chain Antibodies Specific to Lysophosphatidic Acid Receptor 1 (LPA1) from a M13 Phage Display Library Using Purified LPA1 Stabilized in Nanodiscs
    Jung, Ji Hae
    Han, Seong-Gu
    Ju, Man-Seok
    Jung, Sang Taek
    Yu, Yeon Gyu
    BULLETIN OF THE KOREAN CHEMICAL SOCIETY, 2019, 40 (07): : 680 - 685
  • [49] Lysophosphatidic acid (LPA) receptor LPA1/Edg2 generates both the stimulatory and inhibitory signals for Rac and cell migration
    Sugimoto, N
    Takuwa, N
    Takuwa, Y
    FASEB JOURNAL, 2005, 19 (04): : A681 - A681
  • [50] Discovery of an Oxycyclohexyl Acid Lysophosphatidic Acid Receptor 1 (LPA1) Antagonist BMS-986278 for the Treatment of Pulmonary Fibrotic Diseases
    Cheng, Peter T. W.
    Kaltenbach, Robert F.
    Zhang, Hao
    Shi, Jun
    Tao, Shiwei
    Li, Jun
    Kennedy, Lawrence J.
    Walker, Steven J.
    Shi, Yan
    Wang, Ying
    Dhanusu, Suresh
    Reddigunta, Ramesh
    Kumaravel, Selvakumar
    Jusuf, Sutjano
    Smith, Daniel
    Krishnananthan, Subramaniam
    Li, Jianqing
    Wang, Tao
    Heiry, Rebekah
    Sum, Chi Shing
    Kalinowski, Stephen S.
    Hung, Chen-Pin
    Chu, Ching-Hsuen
    Azzara, Anthony, V
    Ziegler, Milinda
    Burns, Lisa
    Zinker, Bradley A.
    Boehm, Stephanie
    Taylor, Joseph
    Sapuppo, Julia
    Mosure, Kathy
    Everlof, Gerry
    Guarino, Victor
    Zhang, Lisa
    Yang, Yanou
    Ruan, Qian
    Xu, Carrie
    Apedo, Atsu
    Traeger, Sarah C.
    Cvijic, Mary Ellen
    Lentz, Kimberley A.
    Tirucherai, Giridhar
    Sivaraman, Lakshmi
    Robl, Jeffrey
    Ellsworth, Bruce A.
    Rosen, Glenn
    Gordon, David A.
    Soars, Matthew G.
    Gill, Michael
    Murphy, Brian J.
    JOURNAL OF MEDICINAL CHEMISTRY, 2021, 64 (21) : 15549 - 15581