Synergistic effect of combined treatment with gamma-tocotrienol and statin on human malignant mesothelioma cells

被引：16
|
作者：
Tuerdi, Guligena [1 ]
Ichinomiya, Saki [1 ]
Sato, Hiromi [1 ]
Siddig, Sana [1 ]
Suwa, Eriko [1 ]
Iwata, Hiroki [1 ]
Yano, Tomohiro [2 ]
Ueno, Koichi [1 ]
机构：
[1] Chiba Univ, Grad Sch Pharmaceut Sci, Dept Geriatr Pharmacol & Therapeut, Chuo Ku, Chiba 2608675, Japan
[2] Toyo Univ, Fac Life Sci, Itakura, Gunma 3740193, Japan
来源：
CANCER LETTERS | 2013年 / 339卷 / 01期
关键词：
Gamma tocotrienol; Statin; Mesothelioma; Mevalonate pathway; Apoptosis; CISPLATIN-INDUCED CYTOTOXICITY; COENZYME-A REDUCTASE; BREAST-CANCER CELLS; CASPASE-3; ACTIVATION; PLEURAL MESOTHELIOMA; MEVALONATE PATHWAY; INDUCED APOPTOSIS; HUMAN LIVER; RECEPTOR; INHIBITION;
D O I：
10.1016/j.canlet.2013.07.015
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The present study is the first to demonstrate the synergetic effect of statins (atorvastatin and simvastatin) and gamma-tocotrienol (gamma-T3) on human malignant mesothelioma (MM). Statin + gamma-T3 combinations induced greater cell growth inhibition more than each single treatment via inhibition of mevalonate pathway, a well-known target of both gamma-T3 and statins. gamma-T3 was necessary for endoplasmic reticulum stress markers CHOP and GRP78, whereas an intrinsic apoptotic marker, caspase 3 activation was induced only in the presence of statins. Overall, the combination of gamma-T3 and statins could be useful for MM therapy and functions in a complementary style. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：116 / 127
页数：12
相关论文
共 50 条
  • [21] Polysaccharopeptide enhanced the anti-cancer effect of gamma-tocotrienol through activation of AMPK
    Ji Liu
    Eunice Yuen-Ting Lau
    Jiezhong Chen
    Joan Yong
    Kai Dun Tang
    Jessica Lo
    Irene Oi-Lin Ng
    Terence Kin-Wah Lee
    Ming-Tat Ling
    BMC Complementary and Alternative Medicine, 14
  • [22] Gamma-tocotrienol reverses multidrug resistance of breast cancer cells with a mechanism distinct from that of atorvastatin
    Ding, Yuedi
    Peng, Ying
    Deng, Lili
    Fan, Jun
    Huang, Biao
    JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 2017, 167 : 67 - 77
  • [23] Gamma-tocotrienol antagonizes adipogenesis through activation of AMPK/autophagy axis in primary human adipocytes
    Zhao, Lu
    Ha, Jung-Heun
    Kang, Inhae
    Okla, Meshail
    Chung, Soonkyu
    FASEB JOURNAL, 2013, 27
  • [24] GAMMA-TOCOTRIENOL DOES NOT COMPETE WITH MITOXANTRONE TO BE EFFLUXED FROM ABCG2 OVEREXPRESSING CELLS
    Tan, Karl Vern
    San Loh, Sandy Hwei
    Briggs, Deborah
    Kerr, Ian
    Then, Sue-Mian
    JOURNAL OF OIL PALM RESEARCH, 2020, 32 (04): : 630 - 638
  • [25] Gamma-Tocotrienol Modulated Gene Expression in Senescent Human Diploid Fibroblasts as Revealed by Microarray Analysis
    Makpol, Suzana
    Zainuddin, Azalina
    Chua, Kien Hui
    Yusof, Yasmin Anum Mohd
    Ngah, Wan Zurinah Wan
    OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, 2013, 2013
  • [26] Gamma-tocotrienol induces apoptosis and autophagy in prostate cancer cells by increasing intracellular dihydrosphingosine and dihydroceramide
    Jiang, Qing
    Rao, Xiayu
    Kim, Choon Young
    Freiser, Helene
    Zhang, Qingbo
    Jiang, Ziying
    Li, Guilan
    INTERNATIONAL JOURNAL OF CANCER, 2012, 130 (03) : 685 - 693
  • [27] TREATMENT OF MALIGNANT MESOTHELIOMA BY INTRAPLEURAL GAMMA INTERFERON
    BOUTIN, C
    BULLETIN DE L ACADEMIE NATIONALE DE MEDECINE, 1990, 174 (03): : 421 - 427
  • [28] Reduced infiltration of regulatory T cells in tumours from mice fed daily with gamma-tocotrienol supplementa
    Subramaniam, Shonia
    Anandha Rao, Jeya Seela
    Ramdas, Premdass
    Ng, Mei Han
    Kannan Kutty, Methil
    Selvaduray, Kanga Rani
    Radhakrishnan, Ammu Kutty
    CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 2021, 206 (02): : 161 - 172
  • [29] Gamma-Tocotrienol Protects Hematopoietic Stem and Progenitor Cells in Mice after Total-Body Irradiation
    Kulkarni, Shilpa
    Ghosh, Sanchita P.
    Satyamitra, Merriline
    Mog, Steven
    Hieber, Kevin
    Romanyukha, Lyudmila
    Gambles, Kristen
    Toles, Raymond
    Kao, Tzu-Cheg
    Hauer-Jensen, Martin
    Kumar, K. Sree
    RADIATION RESEARCH, 2010, 173 (06) : 738 - 747
  • [30] Eliminating drug resistant breast cancer stem-like cells with combination of simvastatin and gamma-tocotrienol
    Gopalan, Archana
    Yu, Weiping
    Sanders, Bob G.
    Kline, Kimberly
    CANCER LETTERS, 2013, 328 (02) : 285 - 296
12345