Bone tissue engineering: from bench to bedside

被引：128

作者：

Woodruff, Maria A. ^{[1
]}

Lange, Claudia ^{[2
]}

Reichert, Johannes ^{[3
]}

Berner, Arne ^{[4
,5
]}

Chen, Fulen

Fratzl, Peter ^{[2
]}

Schantz, Jan-Thorsten ^{[6
]}

Hutmacher, Dietmar W. ^{[1
,7
,8
]}

机构：

[1] Queensland Univ Technol, Inst Hlth & Biomed Innovat, Kelvin Grove 4059, Australia

[2] Max Planck Inst Colloids & Interfaces, Dept Biomat, Potsdam, Germany

[3] Univ Wurzburg, Dept Trauma Hand Plast & Reconstruct Surg, D-97090 Wurzburg, Germany

[4] Univ Regensburg, Dept Trauma Surg, D-93053 Regensburg, Germany

[5] Univ Regensburg, IHBI, D-93053 Regensburg, Germany

[6] Tech Univ Munich, Dept Plast & Handsurg, Klinikum Rechts Isar, D-8000 Munich, Germany

[7] Georgia Inst Technol, Dept Mech Engn, Atlanta, GA 30332 USA

[8] Tech Univ Munich, Inst Adv Study, D-8046 Garching, Germany

来源：

MATERIALS TODAY | 2012年 / 15卷 / 10期

关键词：

ANIMAL-MODELS; TRICALCIUM PHOSPHATE; GROWTH-FACTORS; SCAFFOLDS; POLYCAPROLACTONE; DEFECTS; REPAIR; BIOREACTOR;

D O I：

10.1016/S1369-7021(12)70194-3

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

The drive to develop bone grafts for the filling of major gaps in the skeletal structure has led to a major research thrust towards developing biomaterials for bone engineering. Unfortunately, from a clinical perspective, the promise of bone tissue engineering which was so vibrant a decade ago has so far failed to deliver the anticipated results of becoming a routine therapeutic application in reconstructive surgery. Here we describe our bench to bedside concept, the first clinical results and a detailed analysis of long-term bone regeneration studies in preclinical animal models, exploiting methods of micro- and nano analysis of biodegradable composite scaffolds.

引用

页码：430 / 435

页数：6

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