Silver-Catalyzed Efficient Synthesis of Oxindoles and Pyrroloindolines via α-Aminoalkylation of N-Arylacrylamides with Amino Acid Derivatives

被引：14

作者：

Kanyiva, Kyalo Stephen ^{[1
]}

Makino, Sohei ^{[2
]}

Shibata, Takanori ^{[2
]}

机构：

[1] Waseda Univ, Sch Adv Sci & Engn, Global Ctr Sci & Engn, Shinjuku Ku, Tokyo 1698555, Japan

[2] Waseda Univ, Sch Adv Sci & Engn, Dept Chem & Biochem, Shinjuku Ku, Tokyo 1698555, Japan

来源：

CHEMISTRY-AN ASIAN JOURNAL | 2018年 / 13卷 / 05期

关键词：

amino acids; aminoalkylation; C-H activation; oxindoles; pyrroloindolines; silver; LIGHT PHOTOREDOX CATALYSIS; COUPLING REACTIONS; ACTIVATED ALKENES; CARBOXYLIC-ACIDS; NICKEL CATALYSIS; RADICAL CATIONS; ELECTRON; BOND; HETEROCYCLES; GENERATION;

D O I：

10.1002/asia.201701739

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

alpha-Aminoalkylation of N-arylacrylamides with amino acid derivatives was achieved by silver-catalysis in moderate to high yields. The reaction provides an efficient strategy for the synthesis of functionalized oxindoles, and is suitable for a wide range of N-arylacrylamides and amino acids, both of which are inexpensive and readily available. The oxindoles obtained were readily transformed into densely functionalized pyrroloindolines by deprotection and cyclization in one pot.

引用

页码：496 / 499

页数：4

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