The novel ATR inhibitor VE-821 selectively sensitizes pancreatic cancer cells to radiation and chemotherapy

被引：0
|
作者：
Fokas, E. [1 ]
Prevo, R. [1 ]
Reaper, P. [2 ]
Charlton, P. [2 ]
Pollard, J. [2 ]
McKenna, W. G. [1 ]
Muschel, R. [1 ]
Brunner, T. [1 ]
机构：
[1] Univ Oxford, Dept Oncol, Gray Inst Radiat Oncol & Biol, Oxford, England
[2] Vertex Pharmaceut Europe Ltd Abingdon, Oxford, England
来源：
STRAHLENTHERAPIE UND ONKOLOGIE | 2012年 / 188卷
关键词：
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
引用
收藏
页码：115 / 116
页数：2
相关论文
共 50 条
  • [41] Targeting ATR using a novel ATR inhibitor AZD6738 in human gastric cancer cells
    Min, Ahrum
    Im, Seock-Ah
    Jang, Hyemin
    Kim, Seongyeong
    Lee, Miso
    Kim, Jungeun
    Lee, Kyung-Hun
    Han, Sae-Won
    Kim, Tae-Young
    Oh, Do-Youn
    Kim, Tae-You
    Kim, Woo-Ho
    Bang, Yung-Jue
    CANCER RESEARCH, 2015, 75
  • [42] The Hsp90 inhibitor geldanamycin selectively sensitizes Bcr-Abl-expressing leukemia cells to cytotoxic chemotherapy
    Blagosklonny, MV
    Fojo, T
    Bhalla, KN
    Kim, JS
    Trepel, JB
    Figg, WD
    Rivera, Y
    Neckers, LM
    LEUKEMIA, 2001, 15 (10) : 1537 - 1543
  • [43] The Hsp90 inhibitor geldanamycin selectively sensitizes Bcr-Abl-expressing leukemia cells to cytotoxic chemotherapy
    MV Blagosklonny
    T Fojo
    KN Bhalla
    J-S Kim
    JB Trepel
    WD Figg
    Y Rivera
    LM Neckers
    Leukemia, 2001, 15 : 1537 - 1543
  • [44] The glucosylceramide synthase inhibitor PDMP sensitizes pancreatic cancer cells to MEK/ERK inhibitor AZD-6244
    Wang, Ting
    Wei, Jue
    Wang, Na
    Ma, Jia-Li
    Hui, Ping-Ping
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2015, 456 (03) : 821 - 826
  • [45] A novel NRF2/ARE inhibitor gossypol induces cytotoxicity and sensitizes chemotherapy responses in chemo-refractory cancer cells
    Tang, Ya-Chu
    Chang, Hsin-Huei
    Chen, Huang-Hui
    Yao, Jau-Ying
    Chen, Yu-Tsen
    Chuang, Yung-Jen
    Chang, Jang-Yang
    Kuo, Ching-Chuan
    JOURNAL OF FOOD AND DRUG ANALYSIS, 2021, 29 (04) : 638 - 652
  • [46] Glycogen Synthase Kinase-3 Inhibition Sensitizes Pancreatic Cancer Cells to Chemotherapy by Abrogating the TopBP1/ATR-Mediated DNA Damage Response
    Ding, Li
    Madamsetty, Vijay S.
    Kiers, Spencer
    Alekhina, Olga
    Ugolkov, Andrey
    Dube, John
    Zhang, Yu
    Zhang, Jin-San
    Wang, Enfeng
    Dutta, Shamit K.
    Schmitt, Daniel M.
    Giles, Francis J.
    Kozikowski, Alan P.
    Mazar, Andrew P.
    Mukhopadhyay, Debabrata
    Billadeau, Daniel D.
    CLINICAL CANCER RESEARCH, 2019, 25 (21) : 6452 - 6462
  • [47] Novel focal adhesion kinase 1 inhibitor sensitizes lung cancer cells to radiation in a p53-independent manner
    Jung, Seung-Youn
    Kho, Seongho
    Song, Kyung-Hee
    Ahn, Jiyeon
    Park, In-Chul
    Nam, Ky-Youb
    Hwang, Sang-Gu
    Nam, Seon-Young
    Cho, Seong-Jun
    Song, Jie-Young
    INTERNATIONAL JOURNAL OF ONCOLOGY, 2017, 51 (05) : 1583 - 1589
  • [48] Activation of PPARα by clofibrate sensitizes pancreatic cancer cells to radiation through the Wnt/β-catenin pathway
    Xue, J.
    Zhu, W.
    Song, J.
    Jiao, Y.
    Luo, J.
    Yu, C.
    Zhou, J.
    Wu, J.
    Chen, M.
    Ding, W-Q
    Cao, J.
    Zhang, S.
    ONCOGENE, 2018, 37 (07) : 953 - 962
  • [49] Targeting MUC1-mediated metabolism sensitizes pancreatic cancer cells to radiation therapy
    Gunda, Venugopal
    Abrego, Jaime
    Shukla, Surendra K.
    Chaika, Nina V.
    Yu, Fang
    Bessho, Tadayoshi
    Lin, Chi
    Singh, Pankaj K.
    CANCER RESEARCH, 2015, 75
  • [50] Activation of PPARα by clofibrate sensitizes pancreatic cancer cells to radiation through the Wnt/β-catenin pathway
    J Xue
    W Zhu
    J Song
    Y Jiao
    J Luo
    C Yu
    J Zhou
    J Wu
    M Chen
    W-Q Ding
    J Cao
    S Zhang
    Oncogene, 2018, 37 : 953 - 962
12345