The rate of oxidation of dimethylarsinous acid to dimethylarsinic acid is pH dependent: implications for the analysis and toxicology of arsenic metabolites in urine

被引：0

作者：

Nakayama, T ^{[1
]}

Edmonds, JS ^{[1
]}

Shibata, Y ^{[1
]}

Morita, M ^{[1
]}

机构：

[1] Natl Inst Environm Studies, Endocrine Disrupter Res Lab, Tsukuba, Ibaraki 3058506, Japan

来源：

JOURNAL OF CHEMICAL RESEARCH | 2006年 / 03期

关键词：

dimethylarsinous acid; oxidation; dimethylarsinic acid; H-1 NMR spectroscopy; kinetics;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A H-1 NMR spectroscopic study has shown the rate oxidation of dimethylarsinous acid to dimethylarsinic acid in buffered aqueous solutions to depend upon pH. Dimethylarsinous acid has been reported to be a highly toxic arsenical metabolite and component of the urine of persons exposed to inorganic arsenic, particularly through drinking water. As the pH of human urine can range from 4.5 to 8, the pH dependence of the oxidation rate of dimethylarsinous acid to dimethylarsinic acid has profound implications for the detection and analysis of these compounds in urine samples, and for the relevance of the experimental toxicology of dimethylarsinous acid.

引用

页码：185 / 187

页数：3

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